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Aspirin, Acetaminophen, Caffeine pills
This combination product reduces pain and fever through cyclooxygenase inhibition (aspirin and acetaminophen) while caffeine enhances analgesic efficacy and provides mild stimulation.
This combination product reduces pain and fever through cyclooxygenase inhibition (aspirin and acetaminophen) while caffeine enhances analgesic efficacy and provides mild stimulation. Used for Mild to moderate pain (headache, muscle ache, menstrual cramps, common cold), Fever.
At a glance
| Generic name | Aspirin, Acetaminophen, Caffeine pills |
|---|---|
| Also known as | Excedrin |
| Sponsor | Albert Einstein Healthcare Network |
| Drug class | Analgesic combination product |
| Target | Cyclooxygenase (COX-1, COX-2); adenosine receptors (caffeine) |
| Modality | Small molecule |
| Therapeutic area | Pain Management |
| Phase | FDA-approved |
Mechanism of action
Aspirin irreversibly inhibits cyclooxygenase (COX) enzymes, reducing prostaglandin synthesis and providing anti-inflammatory, analgesic, and antipyretic effects. Acetaminophen inhibits COX enzymes centrally and peripherally to reduce pain and fever through a distinct mechanism. Caffeine acts as a mild central nervous system stimulant and potentiates the analgesic effects of both agents, improving pain relief efficacy.
Approved indications
- Mild to moderate pain (headache, muscle ache, menstrual cramps, common cold)
- Fever
Common side effects
- Gastrointestinal upset
- Heartburn
- Jitteriness or nervousness (caffeine-related)
- Insomnia
- Nausea
Key clinical trials
- Pain Management After Shoulder Arthroplasty (PHASE3)
- Prochlorperazine Versus Acetaminophen, Aspirin, and Caffeine for the Treatment of Acute Migraine (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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