{"id":"aspirin-acetaminophen-caffeine-pills","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Heartburn"},{"rate":null,"effect":"Jitteriness or nervousness (caffeine-related)"},{"rate":null,"effect":"Insomnia"},{"rate":null,"effect":"Nausea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Aspirin irreversibly inhibits cyclooxygenase (COX) enzymes, reducing prostaglandin synthesis and providing anti-inflammatory, analgesic, and antipyretic effects. Acetaminophen inhibits COX enzymes centrally and peripherally to reduce pain and fever through a distinct mechanism. Caffeine acts as a mild central nervous system stimulant and potentiates the analgesic effects of both agents, improving pain relief efficacy.","oneSentence":"This combination product reduces pain and fever through cyclooxygenase inhibition (aspirin and acetaminophen) while caffeine enhances analgesic efficacy and provides mild stimulation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:42:45.860Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Mild to moderate pain (headache, muscle ache, menstrual cramps, common cold)"},{"name":"Fever"}]},"trialDetails":[{"nctId":"NCT04872270","phase":"PHASE3","title":"Pain Management After Shoulder Arthroplasty","status":"UNKNOWN","sponsor":"Rothman Institute Orthopaedics","startDate":"2021-04-15","conditions":"Caffeine, Pain, Joint","enrollment":160},{"nctId":"NCT01629329","phase":"PHASE4","title":"Prochlorperazine Versus Acetaminophen, Aspirin, and Caffeine for the Treatment of Acute Migraine","status":"TERMINATED","sponsor":"Albert Einstein Healthcare Network","startDate":"2010-11","conditions":"Migraine Headaches","enrollment":93}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Excedrin"],"phase":"marketed","status":"active","brandName":"Aspirin, Acetaminophen, Caffeine pills","genericName":"Aspirin, Acetaminophen, Caffeine pills","companyName":"Albert Einstein Healthcare Network","companyId":"albert-einstein-healthcare-network","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination product reduces pain and fever through cyclooxygenase inhibition (aspirin and acetaminophen) while caffeine enhances analgesic efficacy and provides mild stimulation. Used for Mild to moderate pain (headache, muscle ache, menstrual cramps, common cold), Fever.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}