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Amlodipine besylate and folic acid
Amlodipine besylate and folic acid is a Calcium channel blocker + B vitamin supplement Small molecule drug developed by Shenzhen Ausa Pharmed Co.,Ltd. It is currently FDA-approved for Hypertension, Angina pectoris. Also known as: Amlodipine folic acid, Anye, Amlodipine Folic Acid.
Amlodipine besylate blocks L-type calcium channels to reduce blood pressure, while folic acid is a B vitamin that supports cellular methylation and DNA synthesis.
Amlodipine besylate blocks L-type calcium channels to reduce blood pressure, while folic acid is a B vitamin that supports cellular methylation and DNA synthesis. Used for Hypertension, Angina pectoris.
At a glance
| Generic name | Amlodipine besylate and folic acid |
|---|---|
| Also known as | Amlodipine folic acid, Anye, Amlodipine Folic Acid |
| Sponsor | Shenzhen Ausa Pharmed Co.,Ltd |
| Drug class | Calcium channel blocker + B vitamin supplement |
| Target | L-type calcium channel (amlodipine); dihydrofolate reductase (folic acid) |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | FDA-approved |
Mechanism of action
Amlodipine is a dihydropyridine calcium channel blocker that inhibits calcium influx into vascular smooth muscle cells, causing vasodilation and reduced peripheral vascular resistance. Folic acid (vitamin B9) is a cofactor for one-carbon metabolism and nucleotide synthesis, supporting cardiovascular health and reducing homocysteine levels. This combination addresses hypertension while providing nutritional supplementation.
Approved indications
- Hypertension
- Angina pectoris
Common side effects
- Peripheral edema
- Headache
- Flushing
- Fatigue
- Dizziness
Key clinical trials
- China Stroke Primary Prevention Trial 2 for Participants With H-type Hypertension and MTHFR 677 CC/CT Genotype (CSPPT2-CC/CT) (PHASE4)
- China Stroke Primary Prevention Trial 2 for Participants With Hypertension and MTHFR 677 TT Genotype (PHASE4)
- Folic Acid and Intensive Antihypertensive Therapy for Hypertension With CSVD (PHASE4)
- Feasibility Study of the Intensive Systolic Blood Pressure Control (PHASE4)
- Efficacy of Amlodipine-Folic Acid Tablets on Reduction of Blood Pressure and Plasma Homocysteine (PHASE2, PHASE3)
- Efficacy of Amlodipine-folic Acid Tablets on Reduction of Blood Pressure and Plasma Homocysteine (PHASE2, PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Amlodipine besylate and folic acid CI brief — competitive landscape report
- Amlodipine besylate and folic acid updates RSS · CI watch RSS
- Shenzhen Ausa Pharmed Co.,Ltd portfolio CI
Frequently asked questions about Amlodipine besylate and folic acid
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Related
- Drug class: All Calcium channel blocker + B vitamin supplement drugs
- Target: All drugs targeting L-type calcium channel (amlodipine); dihydrofolate reductase (folic acid)
- Manufacturer: Shenzhen Ausa Pharmed Co.,Ltd — full pipeline
- Therapeutic area: All drugs in Cardiovascular
- Indication: Drugs for Hypertension
- Indication: Drugs for Angina pectoris
- Also known as: Amlodipine folic acid, Anye, Amlodipine Folic Acid
- Compare: Amlodipine besylate and folic acid vs similar drugs
- Pricing: Amlodipine besylate and folic acid cost, discount & access