{"id":"amlodipine-besylate-and-folic-acid","safety":{"commonSideEffects":[{"rate":"5-10","effect":"Peripheral edema"},{"rate":"7-16","effect":"Headache"},{"rate":"4-6","effect":"Flushing"},{"rate":"4-5","effect":"Fatigue"},{"rate":"3-7","effect":"Dizziness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Amlodipine is a dihydropyridine calcium channel blocker that inhibits calcium influx into vascular smooth muscle cells, causing vasodilation and reduced peripheral vascular resistance. Folic acid (vitamin B9) is a cofactor for one-carbon metabolism and nucleotide synthesis, supporting cardiovascular health and reducing homocysteine levels. This combination addresses hypertension while providing nutritional supplementation.","oneSentence":"Amlodipine besylate blocks L-type calcium channels to reduce blood pressure, while folic acid is a B vitamin that supports cellular methylation and DNA synthesis.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:27:11.525Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertension"},{"name":"Angina pectoris"}]},"trialDetails":[{"nctId":"NCT04974138","phase":"PHASE4","title":"China Stroke Primary Prevention Trial 2 for Participants With H-type Hypertension and MTHFR 677 CC/CT Genotype (CSPPT2-CC/CT)","status":"RECRUITING","sponsor":"Shenzhen Ausa Pharmed Co.,Ltd","startDate":"2024-08-22","conditions":"Hypertension, MTHFR 677 CC or CT Genotype, Elevated Plasma Homocysteine (Hcy≥10µmol/L)","enrollment":32000},{"nctId":"NCT04974151","phase":"PHASE4","title":"China Stroke Primary Prevention Trial 2 for Participants With Hypertension and MTHFR 677 TT Genotype","status":"RECRUITING","sponsor":"Shenzhen Ausa Pharmed Co.,Ltd","startDate":"2024-08-22","conditions":"Hypertension, MTHFR 677 TT Genotype","enrollment":24000},{"nctId":"NCT05169021","phase":"PHASE4","title":"Folic Acid and Intensive Antihypertensive Therapy for Hypertension With CSVD","status":"NOT_YET_RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2021-12-31","conditions":"Cerebral Small Vessel Diseases, Stroke","enrollment":15000},{"nctId":"NCT02817503","phase":"PHASE4","title":"Feasibility Study of the Intensive Systolic Blood Pressure Control","status":"UNKNOWN","sponsor":"Second Affiliated Hospital of Nanchang University","startDate":"2015-12","conditions":"Hypertension, Hyperhomocysteinemia","enrollment":100},{"nctId":"NCT01956786","phase":"PHASE2, PHASE3","title":"Efficacy of Amlodipine-Folic Acid Tablets on Reduction of Blood Pressure and Plasma Homocysteine","status":"UNKNOWN","sponsor":"Shenzhen Ausa Pharmed Co.,Ltd","startDate":"2013-09","conditions":"Essential Hypertension","enrollment":540},{"nctId":"NCT01848873","phase":"PHASE2, PHASE3","title":"Efficacy of Amlodipine-folic Acid Tablets on Reduction of Blood Pressure and Plasma Homocysteine","status":"UNKNOWN","sponsor":"Shenzhen Ausa Pharmed Co.,Ltd","startDate":"2013-01","conditions":"Essential Hypertension","enrollment":756}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Amlodipine folic acid","Anye","Amlodipine Folic Acid"],"phase":"marketed","status":"active","brandName":"Amlodipine besylate and folic acid","genericName":"Amlodipine besylate and folic acid","companyName":"Shenzhen Ausa Pharmed Co.,Ltd","companyId":"shenzhen-ausa-pharmed-co-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Amlodipine besylate blocks L-type calcium channels to reduce blood pressure, while folic acid is a B vitamin that supports cellular methylation and DNA synthesis. Used for Hypertension, Angina pectoris.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}