Last reviewed 2026-04-20 · How we verify

Differin (ADAPALENE)

Differin works by binding to retinoic acid receptors on the skin's surface, which helps to prevent clogged pores and reduce inflammation.

Differin (Adapalene) is a topical retinoid medication originally developed by Galderma Labs LP and approved by the FDA in 1996 for the treatment of acne vulgaris. It works by targeting the retinoic acid receptor beta, a key component in the development of acne. As a small molecule retinoid, Differin is available as a generic medication, with multiple manufacturers offering their versions. Despite being off-patent, Differin remains a widely used treatment for acne due to its efficacy and safety profile. Its commercial status and availability have contributed to its continued use in dermatological practices.

At a glance

Mechanism of action

Mechanism of Action:. Adapalene acts on retinoid receptors. Biochemical and pharmacological profile studies have demonstrated that adapalene is modulator of cellular differentiation, keratinization, and inflammatory processes all of which represent important features in the pathology of acne vulgaris.Mechanistically, adapalene binds to specific retinoic acid nuclear receptors but does not bind to the cytosolic receptor protein. Although the exact mode of action of adapalene is unknown, it is suggested that topical adapalene normalizes the differentiation of follicular epithelial cells resulting in decreased microcomedone formation.

Approved indications

• Acne vulgaris

Common side effects

• Skin burning sensation
• Erythema
• Dry skin
• Skin exfoliation
• Skin irritation
• Pain of skin
• Chemical burn of skin
• Inappropriate schedule of product administration
• Skin swelling
• Pruritus
• Acne
• Swelling face

Key clinical trials

• Topical 5% Spironolactone Gel Versus 0.1% Adapalene Gel for Acne Vulgaris: A Randomized Split-Face Study (PHASE2)
• Evaluation of Topical Dutasteride as a Potential New Therapy for Facial Acne Vulgaris Versus the Triple Combination Therapy (Clindamycin Phosphate 1.2%, Benzoyl Peroxide 3.1%, and Adapalene 0.15% Gel) (NA)
• Clindamycin Phosphate, Adapalene, and Benzoyl Peroxide Triple Combination Gel in Canadian Patients With Acne Vulgaris
• Auricular Acupressure Combined With Adapalene for the Treatment of Acne Vulgaris (NA)
• Experience With Topical Acne Treatment (EARLY_PHASE1)
• Assessment of the Efficacy of Topical Ketoconazole 2% Cream in Comparison With Topical Retinoids in the Treatment of Mild Comedonal and Papulopustular Acne (NA)
• Study to Compare the Safety and Efficacy of IDP-126 Gel to Epiduo® Forte Gel and Vehicle Gel (PHASE2)
• A Study Assessing the Efficacy of Combined Use of Clascoterone 1% Cream and Adapalene 0.3% for the Treatment of Acne (PHASE4)

Patents

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.