Last reviewed · How we verify
Migraine
Approved treatments
- Ajovy · Teva
Ajovy works by blocking the action of calcitonin gene-related peptide 1 (CGRP1), a molecule involved in pain transmission. - Maxalt · Gensco
Maxalt works by binding to serotonin receptors in the brain to relieve migraine pain. - Frova · Endo Operations
Frova works by binding to serotonin receptors in the brain to relieve migraine symptoms. - Ubrelvy · AbbVie
Ubrelvy blocks the action of a molecule called calcitonin gene-related peptide, which is involved in migraine pain. - Norgesic · Hikma
- OXETORONE
Oxetorone is thought to work by modulating the activity of certain neurotransmitters involved in pain transmission. - Ergot · Samuel Lunenfeld Research Institute, Mount Sinai Hospital
- VYEPTI · Lundbeck Seattle BioPharmaceuticals, Inc.
- Lisurid
Lisuride works by binding to and activating the alpha-2A adrenergic receptor, which helps to regulate various physiological processes. - Nurtec Odt · Pfizer
Rimegepant is a calcitonin gene-related peptide receptor antagonist. - Vyepti · Lundbeck Seattle BioPharmaceuticals, Inc.
Vyepti works by blocking the action of calcitonin gene-related peptide 1, a molecule involved in migraine pain. - Reyvow · Eli Lilly
Reyvow works by binding to the 5-HT1F receptor, blocking pain signals in the brain. - phenobarbitone · Institute of Child Health
- Norgesic · Endo
Orphenadrine citrate centrally acts on brain stem to selectively block facilitatory reticular functions. - Axert · Johnson & Johnson
Axert works by binding to serotonin receptors in the brain to relieve migraine pain. - PF-07976016 Formulation A · Pfizer
- Migranal · Bausch Health
- Zomig · AstraZeneca
Zolmitriptan works by binding to serotonin receptors in the brain to constrict blood vessels and block pain pathways. - Acetaminophen · Polymedica
Acetaminophen works by blocking pain signals in the brain. - Aimovig · Amgen
Aimovig works by blocking the calcitonin-gene-related peptide receptor, a protein involved in migraine pain. - Nurtec Odt · Pfizer
Rimegepant blocks the calcitonin gene-related peptide receptor. - Relpax · Upjohn
- Imitrex · GSK
Imitrex works by binding to serotonin receptors in the brain, specifically the 5-HT1D subtype, to constrict blood vessels and block pain pathways. - Emgality · Eli Lilly
Emgality works by binding to calcitonin gene-related peptide 1 (CGRP1), preventing it from triggering migraine attacks. - Migergot
- Amerge · GSK
Naratriptan treats migraines by binding to 5-HT 1B/1D receptors, causing cranial vessel constriction and inhibiting neuropeptide release. - Vioxx · M.D. Anderson Cancer Center
- Aleve · Generic (originally Syntex)
Reversibly inhibits COX-1 and COX-2 with a long half-life, providing sustained anti-inflammatory, analgesic, and antipyretic effects.
Clinical guidelines
- FDA label — 1L
temporarily relieves migraine
Competitive intelligence
For the full treatment-landscape CI brief — marketed leaders side-by-side, pipeline by phase, recent regulatory actions, sponsor landscape: