Last reviewed 2026-04-20 · How we verify

Amerge (NARATRIPTAN)

Naratriptan treats migraines by binding to 5-HT 1B/1D receptors, causing cranial vessel constriction and inhibiting neuropeptide release.

Naratriptan (Amerge), marketed by GSK, is a 5-HT 1B/1D receptor agonist used for the acute treatment of migraine, competing in a crowded market with several same-class drugs. Its key strength lies in its patent protection until 2028, providing a longer exclusivity period compared to off-patent competitors like zolmitriptan and almotriptan. The primary risk is the strong competition from other branded triptans, such as rizatriptan, which has patent protection until July 30, 2034.

At a glance

Mechanism of action

Naratriptan works by binding to specific receptors in the brain that help control blood vessel size and reduce inflammation. By doing so, it narrows blood vessels and prevents the release of pain-causing substances, thus relieving migraine symptoms.

Approved indications

• Acute treatment of migraine

Common side effects

• Atypical sensation
• Paresthesias (all types)
• Gastrointestinal
• Nausea
• Neurological
• Dizziness
• Drowsiness
• Malaise/fatigue
• Pain and pressure sensation
• Throat/neck symptoms

Drug interactions

• Ergot-containing drugs (e.g., ergotamine, dihydroergotamine, methysergide)
• Other 5-HT 1B/1D agonists (including triptans)
• Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin Norepinephrine Reuptake Inhibitors (SNRIs), Tricyclic Antidepressants (TCAs), Monoamine Oxidase Inhibitors (MAO inhibitors)

Key clinical trials

• Treatments of Migraine with Triptans in Individuals with Elevated Cardiovascular Risk and in Pregnant Women
• Status Migrainosus - Differentiating Between Responders and Non-responders (PHASE1,PHASE2)
• Does Treximet Improve Productivity and Patient Satisfaction Due to Sustained Response and Consistency of Response? (PHASE4)
• Bioequivalency Study of Naratriptan Hydrochloride 2.5 mg Under Fed Conditions (NA)
• Bioequivalency Study of Naratriptan Hydrochloride 2.5 mg Under Fasted Conditions (NA)
• Treximet ™ Pharmacy Budget Impact Model Database Validation Study
• Non-steroidal Anti-inflammatory Drugs Alone or With a Triptan and Reports of Transition From Episodic to Chronic Migraine
• Efficacy and Safety of a Fixed-dose Combination of Naratriptan and Naproxen in Acute Treatment of Migraine (PHASE3)

Primary sources

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