Major Depressive Disorder — Patent Landscape

Aggregated US Orange Book patent estate across every approved drug for major depressive disorder. 105 active patents protecting 3 drugs from 3+ originators. First major cliff: 2027. Daily refresh.

3
Approved drugs
105
Active US patents
48/100
Avg vulnerability
$2.7B
Annual revenue covered

Originators in Major Depressive Disorder

Companies holding active patents on drugs approved for this indication. Click through to each company's full patent dashboard.

Eli Lilly 56 patents Otsuka 46 patents Pfizer 3 patents

Cliff calendar — next 15 years

Patent expiries per year across all drugs treating major depressive disorder. Each bar = one year. Y-axis scaled to peak year (36 patents).

24
26
3
27
6
28
6
29
36
31
9
32
9
33

Approved drugs ranked by patent estate

Drug Originator Active patents Avg vuln Revenue First cliff
Zyprexa
olanzapine
 Eli Lilly 56 64 $300M 2031-08-23
Rexulti
BREXPIPRAZOLE
 Otsuka 46 59 $1.4B 2026-10-12
Pristiq
Desvenlafaxine Succinate
 Pfizer 3 20 $1.0B 2027-07-05

Most attackable patents

Highest vulnerability scores in the indication — paragraph IV / IPR / design-around candidates.

Patent Drug Type Vuln Expiry
12194035 Zyprexa method of use 81 2031-08-23
12194035 Zyprexa method of use 81 2031-08-23
12194035 Zyprexa method of use 81 2031-08-23
12194035 Zyprexa method of use 81 2031-08-23
7888362 Rexulti other 80 2026-10-12
7888362 Rexulti other 80 2026-10-12
8349840 Rexulti other 80 2026-10-12
8618109 Rexulti other 80 2026-10-12
8618109 Rexulti other 80 2026-10-12
7888362 Rexulti other 80 2026-10-12

Strongest defences

Lowest vulnerability scores — pillars of the indication's IP fortress.

Patent Drug Type Vuln Expiry
9119848 Zyprexa composition of matter 10 2031-08-30
9119848 Zyprexa composition of matter 10 2031-08-30
9119848 Zyprexa composition of matter 10 2031-08-30
9119848 Zyprexa composition of matter 10 2031-08-30
RE48059 Rexulti composition of matter 17 2028-12-23
RE48059 Rexulti composition of matter 17 2028-12-23
RE48059 Rexulti composition of matter 17 2028-12-23
RE48059 Rexulti composition of matter 17 2028-12-23
RE48059 Rexulti composition of matter 17 2028-12-23
RE48059 Rexulti composition of matter 17 2028-12-23

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