Last reviewed · How we verify
BRAF mutation-positive colorectal cancer
Approved treatments
- Mektovi · Pfizer
Mektovi works by blocking a specific enzyme called MEK1, which is involved in sending signals that promote cancer cell growth. - Mektovi · Pfizer
Mektovi works by blocking the MEK1 enzyme, which is a key player in the signaling pathway that promotes cancer cell growth. - Braftovi · Pfizer
Braftovi works by blocking the activity of a specific protein called BRAF that is involved in cancer cell growth.
Clinical guidelines
- FDA label — 1L
BRAFTOVI in combination with cetuximab and fluorouracil-based chemotherapy for the treatment of adult patients with metastatic colorectal cancer (mCRC) with a BRAF V600E mutation. - FDA label — 2L
BRAFTOVI in combination with cetuximab for the treatment of adult patients with mCRC with a BRAF V600E mutation, after prior therapy.
Competitive intelligence
For the full treatment-landscape CI brief — marketed leaders side-by-side, pipeline by phase, recent regulatory actions, sponsor landscape:
- BRAF mutation-positive colorectal cancer patent landscape — cliff calendar, originator estates, attackable patents
- BRAF mutation-positive colorectal cancer treatment landscape brief
- BRAF mutation-positive colorectal cancer treatment updates RSS
Frequently asked questions about BRAF mutation-positive colorectal cancer
What drugs treat BRAF mutation-positive colorectal cancer?
Tracked treatments include Mektovi, Braftovi.
What is the treatment for BRAF mutation-positive colorectal cancer?
Standard treatment for BRAF mutation-positive colorectal cancer includes Mektovi, Braftovi. See the treatment landscape page for first-line, second-line and salvage options.
What are the treatment guidelines for BRAF mutation-positive colorectal cancer?
FDA label publishes guidelines for BRAF mutation-positive colorectal cancer. 2 guideline references tracked.
Related
- Treatment landscape: BRAF mutation-positive colorectal cancer patent cliff · BRAF mutation-positive colorectal cancer CI report
- Treatment: Mektovi · Pfizer
- Treatment: Mektovi · Pfizer
- Treatment: Braftovi · Pfizer
- All diseases: Browse the disease index · Disease landscape hub
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing