Otsuka Holdings Co., Ltd. (OTSKY)

Quick facts

Marketed products

• Rexulti · Neuroscience · revenue 1400
• Samsca · Metabolic · revenue 1200
  Samsca works by blocking the action of vasopressin, a hormone that regulates water levels in the body.
• Pletal · Metabolic
• Moizerto · Immunology
• Tomefloxacin · Infectious Disease
• Inqovi · Oncology
  Inqovi works by blocking the enzyme cytidine deaminase, allowing chemotherapy medications to be more effective.
• Physulime · Hematology
• Placebo of tolvaptan
  A placebo formulation containing no active pharmaceutical ingredient, used as a control comparator in clinical trials of tolvaptan.

Phase 3 pipeline

• Aripiprazole (Fixed dose) · Psychiatry
  Aripiprazole is a partial agonist at dopamine D2 and serotonin 5-HT1A receptors that stabilizes dopamine and serotonin neurotransmission in the brain.
• Aripiprazole oral product
• Aripiprazole (Titrated dose) · Psychiatry/Neurology
  Aripiprazole is a partial agonist at dopamine D2 and serotonin 5-HT1A receptors that modulates dopaminergic and serotonergic neurotransmission in the brain.
• ASC-01 · Endocrinology / Musculoskeletal
  ASC-01 is a selective androgen receptor modulator (SARM) that activates androgen signaling in a tissue-selective manner.
• Carteolol long-acting ophthalmic solution · Ophthalmology
  Carteolol is a non-selective beta-adrenergic receptor antagonist that reduces intraocular pressure by decreasing aqueous humor production in the eye.
• CDP870 · Immunology
  CDP870 is a pegylated TNF-alpha inhibitor that binds and neutralizes tumor necrosis factor-alpha to reduce inflammatory responses.
• Hyalein Mini Ophthalmic solution · Ophthalmology
  Hyalein Mini is a hyaluronic acid-based ophthalmic solution that lubricates and protects the ocular surface.
• OPC-1085EL ophthalmic solution · Ophthalmology
  OPC-1085EL ophthalmic solution is an anti-inflammatory agent.
• OPC-12759 · Psychiatry
  OPC-12759 is a selective dopamine D2 receptor antagonist.
• OPC-12759 Ophthalmic suspension · Ophthalmology
  OPC-12759 is an ophthalmic suspension used to treat dry eye syndrome by increasing tear production.
• OPC-14597 (Aripiprazole) · Psychiatry / Neurology
  Aripiprazole is a partial agonist at dopamine D2 and serotonin 5-HT1A receptors that stabilizes dopaminergic and serotonergic neurotransmission.
• OPC-34712FUM/ Brexpiprazole fumarate · Psychiatry
  Brexpiprazole is a serotonin-dopamine activity modulator (SDAM) that acts as a partial agonist at dopamine D2 and serotonin 5-HT1A receptors while antagonizing serotonin 5-HT2A receptors.
• OPC-41061 · Cardiovascular / Nephrology
  OPC-41061 is a vasopressin V2 receptor antagonist (vaptан) that blocks water reabsorption in the kidney collecting duct, promoting aquaresis and increasing serum sodium levels.
• OPC-41061 （Tolvaptan) · Cardiovascular
  Tolvaptan is a selective, competitive antagonist of the vasopressin V2 receptor.
• OPC-61815 injection · Oncology / Supportive Care
  OPC-61815 is a selective antagonist of the neurokinin-1 (NK1) receptor that reduces substance P signaling in the central nervous system.
• OPC-6535 · Neurology / Pain
  OPC-6535 is a selective antagonist of the P2X7 receptor, which modulates purinergic signaling involved in inflammatory and immune responses.
• Placebo of Aripiprazole
  This is a placebo control formulation with no active pharmacological mechanism.
• Placebo of CDP870
  This is a placebo control arm and contains no active pharmaceutical ingredient.
• Placebo of SPM 962
  Placebos do not have an active pharmacological mechanism; they are used as controls in clinical trials.
• SPM 962 · Autoimmune diseases
  SPM 962 is a selective, high-affinity, and orally bioavailable small molecule inhibitor of the sphingosine-1-phosphate receptor 1 (S1PR1).
• TEV-48125 · Cardiovascular
  TEV-48125 is a selective, reversible inhibitor of the sodium-activated potassium channel Nav1.5.
• Tolvaptan Oral Tablet · Nephrology / Endocrinology
  Tolvaptan is a selective vasopressin V2-receptor antagonist that blocks water reabsorption in the kidney's collecting duct, promoting aquaresis (water excretion) without significant electrolyte loss.

Phase 2 pipeline

• 13C-uracil · Oncology
  13C-uracil is a radiolabeled analog of the pyrimidine nucleoside uracil, used for PET imaging of pyrimidine metabolism.
• 99mTc sulfur colloid
• Gastric acid inhibitors
• Nalmefene Hydrochloride Hydrate
• OCV-501
• OPC-18
• OPC-249
• Samtasu for I.V. infusion
• SGI-110

Phase 1 pipeline

• 14C-OPS-2071
• Aripiprazole and sertraline
• ASTX660
• OCV-103 and OCV-104
• OPB-31121 phase2
• OPC-14597 IMD
• OPC-415
• Tolvaptan tablet 15mg

Competitive intelligence

For the full portfolio CI brief — phase mix, recent regulatory actions, upcoming PDUFA dates, patent timeline, class-overlap with competitors:

• Otsuka Holdings Co., Ltd. portfolio CI brief
• Otsuka Holdings Co., Ltd. pipeline updates RSS

Frequently asked questions about Otsuka Holdings Co., Ltd.

Related

• Rexulti · Neuroscience
• Samsca · Metabolic
• Pletal · Metabolic
• Moizerto · Immunology
• Tomefloxacin · Infectious Disease
• Sector hub: All tracked pharma companies
• Ticker: OTSKY · OTC