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Carteolol long-acting ophthalmic solution
Carteolol is a non-selective beta-adrenergic receptor antagonist that reduces intraocular pressure by decreasing aqueous humor production in the eye.
Carteolol is a non-selective beta-adrenergic receptor antagonist that reduces intraocular pressure by decreasing aqueous humor production in the eye. Used for Glaucoma, Ocular hypertension.
At a glance
| Generic name | Carteolol long-acting ophthalmic solution |
|---|---|
| Sponsor | Otsuka Pharmaceutical Co., Ltd. |
| Drug class | Beta-adrenergic receptor antagonist (non-selective beta-blocker) |
| Target | Beta-1 and beta-2 adrenergic receptors |
| Modality | Small molecule |
| Therapeutic area | Ophthalmology |
| Phase | Phase 3 |
Mechanism of action
As a beta-blocker applied topically to the eye, carteolol inhibits beta-adrenergic receptors on the ciliary body, which reduces the production and secretion of aqueous humor. This decrease in aqueous humor production lowers intraocular pressure, making it effective for treating glaucoma and ocular hypertension. The long-acting formulation provides sustained drug delivery and prolonged IOP reduction.
Approved indications
- Glaucoma
- Ocular hypertension
Common side effects
- Ocular irritation or discomfort
- Conjunctival hyperemia
- Blurred vision
- Systemic beta-blocker effects (bradycardia, bronchospasm)
Key clinical trials
- Efficacy and Safety Study of OPC-1085EL Ophthalmic Solution in Subjects With Glaucoma or Ocular Hypertension (PHASE3)
- Pharmacokinetic Study of OPC-1085EL Ophthalmic Solution in Healthy Male Adult Volunteers (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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