Actavis Inc.
Quick facts
Marketed products
- Clindamycin/benzoyl peroxide gel · Dermatology
Clindamycin kills acne-causing bacteria while benzoyl peroxide reduces sebum production and provides additional antimicrobial and keratolytic effects. - Finacea · Dermatology
- KADIAN · Pain
- Zyclara® · Dermatology/Oncology
Zyclara is an imiquimod cream that activates toll-like receptors (TLR7 and TLR8) on immune cells to stimulate local and systemic immune responses against skin lesions.
Phase 3 pipeline
- Carac® (Fluorouracil) Cream · Oncology; Dermatology
Fluorouracil is a pyrimidine analog that inhibits thymidylate synthase and gets incorporated into DNA and RNA, disrupting nucleotide synthesis and causing cell death in rapidly dividing cells. - clindamycin phosphate vaginal cream 2% · Infectious Disease / Gynecology
Clindamycin phosphate is a lincosamide antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby killing or inhibiting the growth of anaerobic bacteria and some gram-positive organisms responsible for bacterial vaginosis. - Estrace® Vaginal Cream USP, 0.01% · Gynecology / Menopause
Estrace vaginal cream delivers estradiol directly to vaginal tissue to restore estrogen levels and relieve symptoms of vaginal atrophy and urogenital aging. - Finacea® (Azelaic Acid) Foam · Dermatology
Azelaic acid reduces inflammation and bacterial growth in the skin by inhibiting mitochondrial enzymes and reducing reactive oxygen species production. - Generic Azelaic Acid Foam · Dermatology
Azelaic acid reduces inflammation and bacterial growth in the skin by inhibiting mitochondrial enzymes and reducing reactive oxygen species production. - Generic Budesonide/Formoterol Fumarate Dihydrate · Respiratory/Pulmonology
Budesonide/formoterol combines a corticosteroid that reduces airway inflammation with a long-acting beta-2 agonist that relaxes airway smooth muscle. - Generic Estradiol Vaginal Cream USP, 0.01% · Gynecology / Menopause
Estradiol binds to estrogen receptors in vaginal tissue to restore local estrogen levels and alleviate symptoms of vaginal atrophy and urogenital dysfunction. - Generic Fluorouracil Cream · Oncology; Dermatology
Fluorouracil is a pyrimidine analog that inhibits thymidylate synthase and gets incorporated into DNA and RNA, disrupting nucleotide synthesis and causing cell death in rapidly dividing cells. - Generic Ingenol Mebutate · Dermatology/Oncology
Ingenol mebutate is a protein kinase C activator that induces rapid necrosis of treated cells and promotes immune-mediated destruction of remaining lesions. - Generic Ivermectin Lotion 0.5% · Dermatology / Parasitic Infections
Ivermectin binds to glutamate-gated chloride channels in parasitic organisms, causing paralysis and death of the parasite. - Ingenol Mebutate (Picato®) · Dermatology
Ingenol mebutate is a protein kinase C (PKC) activator that induces rapid necrosis of actinic keratosis cells and promotes immune-mediated clearance of treated lesions. - Ivermectin Cream, 1% · Dermatology
Ivermectin binds to glutamate-gated chloride channels in parasites and arthropods, causing paralysis and death of the organisms. - Nepafenac 0.3% Oph Susp · Ophthalmology
Nepafenac is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin production and inflammation in the eye. - Placebo pressurized metered dose inhaler
A placebo pressurized metered dose inhaler delivers no active pharmaceutical ingredient, serving as a control comparator in clinical trials. - Placebo/Vehicle cream
Placebo/vehicle cream contains no active pharmaceutical ingredient and serves as a control formulation in clinical trials. - Reference-Brinzolamide 1% Ophthalmic suspension · Ophthalmology
Reference-Brinzolamide 1% Ophthalmic suspension works by reducing intraocular pressure by increasing the outflow of aqueous humor. - Rhofade Cream, 1% · Dermatology
Oxymetazoline is an alpha-1 adrenergic agonist that constricts blood vessels in the skin to reduce facial redness and flushing. - Tazarotene (Actavis) · Dermatology
Tazarotene is a retinoid that binds to retinoid X receptors (RXR) and retinoid acid receptors (RAR) to regulate gene expression and promote skin cell differentiation and turnover. - Tazarotene (Fabior™) · Dermatology
Tazarotene is a topical retinoid that modulates the expression of genes involved in cell proliferation and differentiation. - Test-Brinzolamide 1% Ophthalmic suspension · Ophthalmology
Test-Brinzolamide 1% Ophthalmic suspension works by reducing intraocular pressure by increasing the outflow of aqueous humor. - Vehicle Vaginal Cream · Gynecology
Vehicle Vaginal Cream is a topical lubricant used to treat vaginal dryness and discomfort.
Phase 1 pipeline
- Clobex TM 0.05% Lotion, single exposure
- COMBONOX® tablets, single dose
- morphine sulfate sustained-release capsules
- Ultravate® 0.05% ointment, single exposure
Competitive intelligence
For the full portfolio CI brief — phase mix, recent regulatory actions, upcoming PDUFA dates, patent timeline, class-overlap with competitors: