pyrimidine analog

This page covers all pyrimidine analog drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting thymidylate synthase, Thymidylate synthase.

Targets

thymidylate synthase · Thymidylate synthase

Phase 3 pipeline (4)

• mFolfox6 or capecitabine · UNICANCER · Oncology
  capecitabine is a prodrug that is converted into 5-fluorouracil, which is then incorporated into DNA and RNA, interfering with cancer cell replication.
• continuous infusion of 5-fluorouracil · Japan Clinical Oncology Group · Oncology
  5-fluorouracil is a thymidylate synthase inhibitor that disrupts DNA synthesis and function.
• STZ-5FU · Grupo Espanol de Tumores Neuroendocrinos · Oncology
  STZ-5FU is a chemotherapeutic agent that works by interfering with DNA synthesis.
• fluorouracil based chemotherapy regimens · China Medical University, China · Oncology
  Fluorouracil is a thymidylate synthase inhibitor that disrupts DNA synthesis and function.

Phase 2 pipeline (4)

• 5-flourouracil · AstraZeneca · Oncology
  5-fluorouracil is a thymidylate synthase inhibitor that disrupts DNA synthesis in rapidly dividing cancer cells.
• Intralesional 5-fluorouracil · Maharajgunj Medical Campus · Oncology
  Inhibits thymidylate synthase
• Infusional 5-Fluorouracil · Italian Trial in Medical Oncology · Oncology
  Inhibits thymidylate synthase
• 5-Fluoracil · Servicio de Salud Metropolitano Sur Oriente · Oncology
  5-Fluorouracil is a thymidylate synthase inhibitor that disrupts DNA synthesis and function.