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STZ-5FU
STZ-5FU is a chemotherapeutic agent that works by interfering with DNA synthesis.
STZ-5FU is a chemotherapeutic agent that works by interfering with DNA synthesis. Used for Colorectal cancer, Breast cancer.
At a glance
| Generic name | STZ-5FU |
|---|---|
| Also known as | STZ based Chemotherapy |
| Sponsor | Grupo Espanol de Tumores Neuroendocrinos |
| Drug class | pyrimidine analog |
| Target | thymidylate synthase |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | Phase 3 |
Mechanism of action
STZ-5FU is a prodrug that is converted into 5-fluorouracil, which is then incorporated into DNA, causing DNA damage and inhibiting cancer cell growth. This leads to cell death and ultimately, tumor shrinkage.
Approved indications
- Colorectal cancer
- Breast cancer
Common side effects
- Diarrhea
- Nausea
- Vomiting
- Fatigue
- Anemia
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |