Last reviewed · How we verify
Intralesional 5-fluorouracil
Inhibits thymidylate synthase
Inhibits thymidylate synthase Used for Actinic keratosis, Basal cell carcinoma.
At a glance
| Generic name | Intralesional 5-fluorouracil |
|---|---|
| Sponsor | Maharajgunj Medical Campus |
| Drug class | Pyrimidine analog |
| Target | Thymidylate synthase |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | Phase 2 |
Mechanism of action
5-fluorouracil works by inhibiting thymidylate synthase, an enzyme involved in DNA synthesis, thereby preventing cancer cell growth.
Approved indications
- Actinic keratosis
- Basal cell carcinoma
Common side effects
- Mucositis
- Diarrhea
- Fatigue
Key clinical trials
- The Application of Intralesional 5-fluorouracil for the Management of Hypertrophic Facial Scars in the Periocular Region Resulting From Trauma and Surgical Procedures in Individuals Aged Over 18 Years (PHASE4)
- The Efficacy of Intralesional Bleomycin as Compared to 5-Flourouracil (5-FU) and Triamcinolone Acetonide (TAC) for the Treatment of Keloids: A Randomized Control Trial. (NA)
- Efficacy and Safety of Intralesional 5-Fluorouracil and Triamcinolone Acetonide in Keloids and Hypertrophic Scars
- Intralesional 5-Fluorouracil (5FU), Topical Calcipotriene Treatment for SCC (PHASE1)
- A Randomized, Double-blinded, Self-controlled Clinical Study of Intralesional Injection of 5-fluorouracil Plus Triamcinolone for the Treatment of Refractory Nodular Prurigo (PHASE3)
- The Efficacy and Safety of Using Intralesional 5-fluorouracil for Basal Cell Carcinoma (PHASE3)
- Keloid Scarring: Treatment and Pathophysiology (PHASE4)
- Intralesional Injection of Combined Digoxin and Furosemide Versus 5-Flurouracil in Plantar Warts (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Intralesional 5-fluorouracil CI brief — competitive landscape report
- Intralesional 5-fluorouracil updates RSS · CI watch RSS
- Maharajgunj Medical Campus portfolio CI