PET imaging agent

This page covers all PET imaging agent drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Amyloid-beta (Aβ) plaques, Amyloid-beta (Aβ) fibrils, Amyloid-beta plaques.

Targets

Amyloid-beta (Aβ) plaques · Amyloid-beta (Aβ) fibrils · Amyloid-beta plaques · Amino acid transporters (LAT1, ASCT2) · Choline transporter · Tau protein (paired helical filaments) · Choline transporters · PSMA (prostate-specific membrane antigen) · Fibroblast activation protein (FAP) · Dopamine synthesis pathway / Large neutral amino acid transporter

Marketed (4)

• Florbetapir F 18 (18F-AV-45) · University of California, San Francisco · Neurology / Alzheimer's disease
  Florbetapir F-18 is a positron emission tomography (PET) imaging agent that binds to amyloid-beta plaques in the brain to detect Alzheimer's disease pathology.
• [18F]Florbetapir PET imaging · Institute for Neurodegenerative Disorders · Neurology
  [18F]Florbetapir is a positron emission tomography (PET) imaging agent that binds to amyloid-beta plaques in the brain to visualize amyloid pathology.
• Neuraceq (florbetaben 18F) · Piramal Imaging Limited · Neurology / Diagnostic Imaging
  Florbetaben 18F is a positron emission tomography (PET) imaging agent that binds to amyloid-beta plaques in the brain to detect Alzheimer's disease pathology.
• Fluciclovine PET/CT · OHSU Knight Cancer Institute · Oncology
  Fluciclovine is a fluorine-18 labeled amino acid analog that accumulates in cancer cells with high amino acid metabolism, enabling PET/CT imaging detection of malignant lesions.

Phase 3 pipeline (8)

• 11C-choline · University of Michigan · Oncology
  11C-choline is a positron emission tomography (PET) imaging agent that accumulates in tissues with high choline metabolism, enabling visualization of metabolically active lesions.
• Tau PET scan using MK-6240 · University of California, Irvine · Neurology
  MK-6240 is a positron emission tomography (PET) imaging agent that binds to tau protein aggregates in the brain to visualize tau pathology.
• F-choline intravenous injection · Centre hospitalier de l'Université de Montréal (CHUM) · Oncology
  F-choline is a fluorine-18 labeled choline analog used as a positron emission tomography (PET) imaging agent to visualize choline metabolism in tissues.
• Ga-68 labeled PSMA-11 PET · University of California, San Francisco · Oncology
  Ga-68 labeled PSMA-11 is a positron emission tomography (PET) imaging agent that binds to prostate-specific membrane antigen (PSMA) on prostate cancer cells to enable detection and localization.
• [18F]FAPI-74 PET/CT · SOFIE · Oncology
  This drug is a PET imaging agent that targets the fibroblast activation protein (FAP) for the visualization of tumors.
• 18F-DOPA · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) · Neurology / Diagnostic Imaging
  18F-DOPA is a positron emission tomography (PET) imaging agent that accumulates in dopamine-producing tissues, allowing visualization of dopaminergic function and neurological disorders.
• F-18-Fluorocholine · ABX advanced biochemical compounds GmbH · Oncology
  F-18-Fluorocholine is a positron emission tomography (PET) imaging agent that accumulates in cells with high choline metabolism, enabling visualization of metabolically active tissues.
• PET/CT with 18F-DOPA · Central Hospital, Nancy, France · Neurology; Oncology (neuroendocrine tumors)
  18F-DOPA is a positron emission tomography (PET) tracer that accumulates in dopamine-producing tissues, allowing visualization and quantification of dopaminergic function in the brain.

Phase 2 pipeline (1)

• Amyvid, Intravenous Solution · Universidad Central del Caribe · Neurology
  Amyvid is a positron emission tomography (PET) imaging agent that binds to beta-amyloid plaques in the brain.