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11C-choline
11C-choline is a positron emission tomography (PET) imaging agent that accumulates in tissues with high choline metabolism, enabling visualization of metabolically active lesions.
11C-choline is a positron emission tomography (PET) imaging agent that accumulates in tissues with high choline metabolism, enabling visualization of metabolically active lesions. Used for Prostate cancer imaging and detection, Brain tumor imaging, Lung cancer imaging.
At a glance
| Generic name | 11C-choline |
|---|---|
| Also known as | 11C-CH, CCH Injection, C11 Choline Injection |
| Sponsor | University of Michigan |
| Drug class | PET imaging agent |
| Target | Choline transporter |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | Phase 3 |
Mechanism of action
11C-choline is a radiolabeled tracer where carbon-11 is incorporated into choline, a precursor for phosphatidylcholine synthesis. Rapidly dividing and metabolically active cells, including cancer cells, exhibit increased choline uptake and incorporation into cell membranes. The radioactive carbon-11 allows detection via PET imaging, facilitating localization and characterization of tumors.
Approved indications
- Prostate cancer imaging and detection
- Brain tumor imaging
- Lung cancer imaging
Common side effects
- Radiation exposure
Key clinical trials
- PSMA and C-11 Choline PET in Patients With Biochemical Recurrence of Prostate Cancer (EARLY_PHASE1)
- Diagnostic Performance of [11C]Choline PET/CT In the Preoperative Assessment of Primary Hyperparathyroidism
- PSMA Specific [68Ga]-P137 Peptide Probe for PET Imaging in Prostate Cancer (NA)
- A Retrospective Analysis of the Diagnostic Performance of 11C-choline PET/CT in Primary Hyperparathyroidism
- 11C-choline PET/CT Based Helical Tomotherapy as Innovative Treratment Approach for Bone Metastases in Prostate Cancer Patients.
- [Al18F]PSMA137 PET/CT Imaging for PSMA-Positive Cancer Patients (NA)
- PET Study of Acetylcholine Esterase Activity in Alzheimer's Disease
- Radiation Treatment of Lymph Node Recurrence From Prostate Cancer : is 11C-choline PET/CT Predictive of Survival Outcomes?
Primary sources
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| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |