Nucleoside Metabolic Inhibitor

This page covers all Nucleoside Metabolic Inhibitor drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Carbonic anhydrase 5A, mitochondrial, Adenosine deaminase, DNA polymerase (alpha/delta/epsilon).

Targets

Carbonic anhydrase 5A, mitochondrial · Adenosine deaminase · DNA polymerase (alpha/delta/epsilon) · Thymidylate synthase · DNA methyltransferase · Ribonucleotide reductase; DNA incorporation · Ribonucleoside-diphosphate reductase large subunit · Aromatase · DNA (cytosine-5)-methyltransferase 1 · Cytidine deaminase

Marketed (17)

• Fludara · Nihon Schering K.K. · Oncology
  Fludara works by interfering with the production of DNA and RNA in cancer cells, ultimately leading to cell death.
• Nipent · Hospira Inc · Oncology
• Arranon · Novartis · Oncology
  Arranon works by inhibiting the enzyme responsible for converting nucleosides into their active forms, thereby preventing DNA synthesis in cancer cells.
• Gemzar · Accord Hlthcare · Oncology
  Gemzar works by mimicking a building block of DNA, tricking cancer cells into incorporating it into their DNA and then stopping the replication process.
• CYTARABINE
• Xeloda · Cheplapharm · Oncology
  Xeloda works by inhibiting the enzyme thymidylate synthase, which is necessary for DNA synthesis in cancer cells.
• FLUOROURACIL
• CEDAZURIDINE
  Decitabine inhibits DNA methyltransferase, leading to DNA hypomethylation and cellular differentiation or apoptosis.
• Gemzar · Accord Hlthcare · Oncology
  Gemcitabine kills cells during DNA synthesis and blocks G1/S-phase progression.
• Clolar · Sanofi · Oncology
  Clolar works by inhibiting the enzyme responsible for DNA synthesis, thereby preventing cancer cells from reproducing.
• Carac · Spectrum Pharms · Oncology
• Dacogen · Sun Pharma · Oncology
  Dacogen works by inhibiting the enzyme that adds methyl groups to DNA, which helps to restore normal gene function in cancer cells.
• Vidaza · Bristol-Myers Squibb · Oncology
  Vidaza works by incorporating itself into DNA and interfering with the enzyme that adds methyl groups, which helps to restore normal gene function in cancer cells.
• Inqovi · Otsuka · Oncology
  Inqovi works by blocking the enzyme cytidine deaminase, allowing chemotherapy medications to be more effective.
• AZACITIDINE
• Carac · Extrovis · Oncology
• Nipent · Pfizer Inc. · Oncology

Phase 2 pipeline (1)

• Sunrabin · Metabolic
  Sunrabin works by incorporating itself into viral DNA, thereby disrupting its replication and transcription.

Patent intelligence

• nucleoside metabolic inhibitor patent landscape — aggregated cliff calendar, attackable patents, originator estates