Nucleoside analog antiviral

This page covers all Nucleoside analog antiviral drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Viral DNA polymerase (CMV and herpes simplex virus), Viral DNA polymerase (herpes simplex virus and varicella-zoster virus), Viral RNA-dependent RNA polymerase (RdRp).

Targets

Viral DNA polymerase (CMV and herpes simplex virus) · Viral DNA polymerase (herpes simplex virus and varicella-zoster virus) · Viral RNA-dependent RNA polymerase (RdRp) · Viral DNA polymerase (herpesvirus) · Viral RNA-dependent RNA polymerase; inosine monophosphate dehydrogenase (IMPDH) · Viral RNA-dependent RNA polymerase; IMPDH (inosine monophosphate dehydrogenase) · Cytomegalovirus (CMV) DNA polymerase · Viral RNA-dependent RNA polymerase; guanosine triphosphate metabolism · HCV NS5B RNA-dependent RNA polymerase; ribavirin has multiple targets · Herpesvirus DNA polymerase

Marketed (22)

• intravenous (IV) ganciclovir · University of Oslo School of Pharmacy · Infectious Disease / Virology
  Ganciclovir is a nucleoside analog that inhibits viral DNA polymerase, preventing replication of herpes viruses, particularly cytomegalovirus (CMV).
• Acyclovir (ACV) · French National Agency for Research on AIDS and Viral Hepatitis · Infectious Disease / Virology
  Acyclovir is a nucleoside analog that inhibits viral DNA polymerase, preventing replication of herpes simplex virus and varicella-zoster virus.
• standard treatment COVID-19 + Triazavirin · Ain Shams University · Infectious Disease / Virology
  Triazavirin is a nucleoside analog that inhibits viral RNA polymerase to reduce SARS-CoV-2 replication.
• Valacyclovir (ZELITREX) · Assistance Publique - Hôpitaux de Paris · Infectious Disease / Virology
  Valacyclovir is a prodrug that is converted to acyclovir, which inhibits viral DNA polymerase to prevent herpesvirus replication.
• Ribavirin (Copegus®) · Vertex Pharmaceuticals Incorporated · Virology/Infectious Disease
  Ribavirin is a nucleoside analog that inhibits viral RNA synthesis by interfering with guanosine triphosphate pools and viral polymerase activity.
• Ribavirin "loading" dose given · Göteborg University · Virology/Infectious Disease
  Ribavirin is a nucleoside analog that inhibits viral RNA synthesis by interfering with guanosine triphosphate pools and viral polymerase activity.
• VAL · Estetra · Infectious Disease / Virology
  VAL is a valganciclovir prodrug that is converted to ganciclovir in the body to inhibit viral DNA polymerase and prevent cytomegalovirus (CMV) replication.
• ribavirin pre-treatment · University of Roma La Sapienza · Virology/Infectious Disease
  Ribavirin is a nucleoside analog that inhibits viral RNA synthesis by interfering with guanosine triphosphate metabolism and RNA-dependent RNA polymerase activity.
• Sofosbuvir-Ribavirin · Ain Shams University · Virology / Hepatology
  Sofosbuvir inhibits hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase, while ribavirin is a nucleoside analog that enhances viral suppression through multiple mechanisms.
• Experimental: Valacyclovir treatment · University of Pittsburgh · Infectious Disease / Virology
  Valacyclovir is a prodrug that is converted to acyclovir, which inhibits viral DNA polymerase to prevent herpesvirus replication.
• Peginterferon alfa-2a + ribavirin · Hospital Clinico Universitario San Cecilio · Virology / Hepatology
  Peginterferon alfa-2a activates interferon-alpha receptors to enhance antiviral immunity, while ribavirin inhibits viral RNA synthesis, together suppressing hepatitis C virus replication.
• Peg-IFN + WB RBV for 24 weeks · National Taiwan University Hospital · Virology / Hepatology
  Pegylated interferon alpha combined with weight-based ribavirin stimulates the immune system to inhibit hepatitis C virus replication and clearance.
• Lonsurf · Taiho Oncology Inc · Oncology
  Lonsurf works by inhibiting the enzyme thymidine phosphorylase, which is involved in the breakdown of certain cancer medications.
• Copegus (ribavirin) · Hoffmann-La Roche · Virology/Infectious Disease
  Ribavirin is a nucleoside analog that inhibits viral RNA synthesis by interfering with the viral polymerase and depleting guanosine nucleotide pools.
• Ribavirin (R) · Tibotec Pharmaceuticals, Ireland · Virology/Infectious Disease
  Ribavirin is a nucleoside analog that inhibits viral RNA synthesis by interfering with guanosine triphosphate pools and viral polymerase activity.
• valganciclovir [Valcyte] · Hoffmann-La Roche · Infectious Disease / Virology
  Valganciclovir is a prodrug that is converted to ganciclovir, which inhibits viral DNA polymerase and prevents replication of cytomegalovirus (CMV).
• prophylactic Valganciclovir · Rabin Medical Center · Infectious Disease / Virology
  Valganciclovir is a prodrug of ganciclovir that inhibits viral DNA polymerase to prevent cytomegalovirus (CMV) replication in immunocompromised patients.
• Valganciclovir/Ganciclovir · University Health Network, Toronto · Infectious Disease / Virology
  Valganciclovir is a prodrug that is converted to ganciclovir, which inhibits viral DNA polymerase to prevent cytomegalovirus (CMV) replication.
• Ribavirin (SCH 018908) · Merck Sharp & Dohme LLC · Infectious Disease / Virology
  Ribavirin is a nucleoside analog that inhibits viral RNA synthesis by interfering with guanosine triphosphate pools and viral polymerase activity.
• Masked Oral Valacyclovir · NYU Langone Health · Infectious Disease / Virology
  Masked oral valacyclovir is a taste-masked formulation of valacyclovir that inhibits viral DNA polymerase to prevent herpes simplex virus and varicella-zoster virus replication.
• Dendrid · Novartis · Infectious Disease
• Ribavirin in Arm 1 · MinaPharm Pharmaceuticals · Virology/Infectious Disease
  Ribavirin is a nucleoside analog that inhibits viral RNA synthesis by interfering with the viral polymerase and depleting guanosine nucleotide pools.

Phase 3 pipeline (10)

• Placebo matching Ribavirin · Bristol-Myers Squibb · Virology / Infectious Disease
  This is a placebo control matching the appearance and dosing schedule of ribavirin, an antiviral nucleoside analog that inhibits viral RNA synthesis.
• AV5080 · Viriom · Infectious Disease / Virology
  AV5080 is a nucleoside analog that inhibits viral RNA-dependent RNA polymerase, blocking replication of RNA viruses.
• Acyclovir 5 percent (Perrigo) · Padagis LLC · Infectious Disease / Virology
  Acyclovir is a nucleoside analog that inhibits viral DNA polymerase, preventing herpes simplex virus and varicella-zoster virus from replicating.
• Generic acyclovir · University of Washington · Infectious Disease / Virology
  Acyclovir inhibits viral DNA polymerase to prevent replication of herpes simplex virus and varicella-zoster virus.
• P1101 + Ribavirin · PharmaEssentia · Virology / Hepatology
  P1101 is an interferon lambda that enhances antiviral immunity, combined with ribavirin, a nucleoside analog that inhibits viral RNA synthesis.
• "Priming" dose of ribavirin given · Göteborg University · Virology/Infectious Disease
  Ribavirin is a nucleoside analog that inhibits viral RNA synthesis by interfering with guanosine triphosphate metabolism and viral polymerase function.
• Placebo to VGCV · Merck Sharp & Dohme LLC · Infectious Disease / Virology
  VGCV (valganciclovir) is a prodrug of ganciclovir that inhibits viral DNA polymerase to suppress cytomegalovirus (CMV) replication.
• Valganciclovir CMV Prophylaxis · University of California, San Francisco · Infectious Disease / Virology
  Valganciclovir is a prodrug that is converted to ganciclovir, which inhibits cytomegalovirus (CMV) DNA polymerase to prevent viral replication.
• Placebo to ACV · Merck Sharp & Dohme LLC · Infectious Disease / Virology
  This is a Phase 3 trial comparing placebo to acyclovir (ACV), an antiviral nucleoside analog that inhibits viral DNA polymerase to prevent herpes simplex virus replication.
• Molnupiravir (Esperavir) · Promomed, LLC · Infectious Disease / Virology
  Molnupiravir is a nucleoside analog that induces viral mutagenesis by causing errors during viral RNA replication, leading to viral extinction.

Patent intelligence

• nucleoside analog antiviral patent landscape — aggregated cliff calendar, attackable patents, originator estates