Guanylate cyclase-C agonist

This page covers all Guanylate cyclase-C agonist drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting GC-C (guanylate cyclase-C receptor), GC-C (guanylate cyclase-C).

Targets

GC-C (guanylate cyclase-C receptor) · GC-C (guanylate cyclase-C)

Marketed (2)

• Linaclotide 72 micrograms · Md Mehedi Shahriar · Gastroenterology
  Linaclotide is a guanylate cyclase-C (GC-C) agonist that increases intracellular cyclic GMP in intestinal epithelial cells, promoting fluid secretion and accelerating intestinal transit.
• XOI · Ironwood Pharmaceuticals, Inc. · Gastroenterology
  XOI is a guanylate cyclase-C (GC-C) agonist that increases intracellular cGMP in intestinal epithelial cells to promote fluid secretion and bowel motility.

Phase 3 pipeline (1)

• AJG555 · EA Pharma Co., Ltd. · Gastroenterology
  AJG555 is a guanylate cyclase-C (GC-C) agonist that increases intracellular cGMP to promote fluid secretion and accelerate intestinal transit.