Sympathomimetic amine; CNS stimulant

This page covers all Sympathomimetic amine; CNS stimulant drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Dopamine transporter (DAT); Norepinephrine transporter (NET), Alpha-2 adrenergic receptors (cyclobenzaprine); adenosine receptors (caffeine).

Targets

Dopamine transporter (DAT); Norepinephrine transporter (NET) · Alpha-2 adrenergic receptors (cyclobenzaprine); adenosine receptors (caffeine)

Marketed (14)

• Aptensio XR · Rhodes Pharmaceuticals, L.P. · Psychiatry/Neurology
  Aptensio XR is an extended-release formulation of methylphenidate that increases dopamine and norepinephrine activity in the central nervous system to improve attention and reduce hyperactivity.
• Methylphenidate (MPD) · University of Cincinnati · Neurology; Psychiatry
  Methylphenidate blocks the reuptake of dopamine and norepinephrine in the central nervous system, increasing their availability in the brain.
• SODAS methylphenidate HCl · Massachusetts General Hospital · Neurology; Psychiatry
  SODAS methylphenidate HCl is a sustained-release formulation of methylphenidate that inhibits the reuptake of dopamine and norepinephrine in the central nervous system.
• Methylphenidate extended-release liquid formulation · Massachusetts General Hospital · Neurology; Psychiatry
  Methylphenidate blocks the reuptake of dopamine and norepinephrine in the central nervous system, increasing their availability at the synapse.
• Short Acting Methylphenidate · BRC Operations Pty. Ltd. · Neurology; Psychiatry
  Short-acting methylphenidate blocks the reuptake of dopamine and norepinephrine in the central nervous system, increasing their availability at the synapse.
• Long acting methylphenidate · University of California, Los Angeles · Neurology; Psychiatry
  Long-acting methylphenidate is a sustained-release formulation of a central nervous system stimulant that increases dopamine and norepinephrine availability in the brain by inhibiting their reuptake.
• Dyanavel XR · Rochester Center for Behavioral Medicine · Psychiatry / Neurology
  Dyanavel XR is an extended-release liquid formulation of amphetamine that increases the release of dopamine and norepinephrine in the central nervous system to improve attention and reduce hyperactivity.
• mixed salts amphetamine · Rush University Medical Center · Psychiatry / Neurology
  Mixed salts amphetamine increases the release and blocks the reuptake of dopamine and norepinephrine in the central nervous system, enhancing attention and reducing impulsivity.
• CNS Stimulant · Milton S. Hershey Medical Center · Neurology / Psychiatry
  CNS stimulants increase the activity of the central nervous system by enhancing the release or blocking the reuptake of neurotransmitters such as dopamine and norepinephrine.
• Serdexmethylphenidate/dexmethylphenidate · NYU Langone Health · Neurology/Psychiatry
  Serdexmethylphenidate is a prodrug that is metabolized to dexmethylphenidate, which inhibits the reuptake of dopamine and norepinephrine in the central nervous system.
• Methylphenidate Oral Solution · University of California, Davis · Neurology; Psychiatry
  Methylphenidate blocks the reuptake of dopamine and norepinephrine in the central nervous system, increasing their availability in the brain.
• methylphenidate HCl (Concerta) · Massachusetts General Hospital · Neurology / Psychiatry
  Methylphenidate blocks the reuptake of dopamine and norepinephrine in the central nervous system, increasing their availability in the brain.
• Methylphenidate (MPH) · University of California, Los Angeles · Neurology; Psychiatry
  Methylphenidate blocks the reuptake of dopamine and norepinephrine in the central nervous system, increasing their availability in the brain.
• Adderall ® Immediate Release · NYU Langone Health · Neurology / Psychiatry
  Adderall is a combination of amphetamine salts that increases the release and blocks the reuptake of dopamine and norepinephrine in the central nervous system, enhancing focus and attention.

Phase 3 pipeline (5)

• Methylphenidate (OROS-MPH) · University of Cincinnati · Neurology / Psychiatry
  Methylphenidate is a central nervous system stimulant that increases dopamine and norepinephrine activity in the brain by blocking their reuptake at the synapse.
• Cyclobenzaprine with caffeine · EMS · Neurology / Pain Management
  Cyclobenzaprine is a muscle relaxant that reduces muscle tension through central nervous system depression, while caffeine is a stimulant that counteracts sedation and enhances alertness.
• Dexmethylphenidate HCl extended-release capsules · Novartis · Neurology/Psychiatry
  Dexmethylphenidate HCl is a central nervous system stimulant that increases dopamine and norepinephrine activity in the brain by blocking their reuptake at the presynaptic neuron.
• Mixed Amphetamine Salts, ER · Seattle Children's Hospital · Psychiatry/Neurology
  Mixed amphetamine salts increase the release and block the reuptake of dopamine and norepinephrine in the central nervous system, enhancing attention and reducing impulsivity.
• Dexamfetamine sulphate · Assistance Publique - Hôpitaux de Paris · Neurology; Psychiatry
  Dexamfetamine sulphate is a central nervous system stimulant that increases the release and blocks the reuptake of dopamine and norepinephrine in the brain.

Patent intelligence

• cns stimulant patent landscape — aggregated cliff calendar, attackable patents, originator estates