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Mixed Amphetamine Salts, ER
Mixed amphetamine salts increase the release and block the reuptake of dopamine and norepinephrine in the central nervous system, enhancing attention and reducing impulsivity.
Mixed amphetamine salts increase the release and block the reuptake of dopamine and norepinephrine in the central nervous system, enhancing attention and reducing impulsivity. Used for Attention-deficit/hyperactivity disorder (ADHD) in children and adolescents.
At a glance
| Generic name | Mixed Amphetamine Salts, ER |
|---|---|
| Also known as | Adderall XR |
| Sponsor | Seattle Children's Hospital |
| Drug class | Sympathomimetic amine; CNS stimulant |
| Target | Dopamine transporter (DAT); Norepinephrine transporter (NET) |
| Modality | Small molecule |
| Therapeutic area | Psychiatry/Neurology |
| Phase | Phase 3 |
Mechanism of action
This combination of amphetamine isomers acts as a sympathomimetic amine that stimulates the release of catecholamines (dopamine and norepinephrine) from presynaptic neurons and inhibits their reuptake, leading to increased synaptic concentrations. The extended-release formulation provides sustained therapeutic levels throughout the day. This mechanism improves executive function, attention span, and impulse control in patients with attention-deficit/hyperactivity disorder (ADHD).
Approved indications
- Attention-deficit/hyperactivity disorder (ADHD) in children and adolescents
Common side effects
- Insomnia
- Decreased appetite
- Headache
- Abdominal pain
- Nervousness/anxiety
- Tachycardia
- Elevated blood pressure
Key clinical trials
- A Sequenced Behavioral and Medication Intervention for Cocaine Dependence (PHASE1, PHASE2)
- Sleep and Tolerability Study: Comparing the Effects of Adderall XR and Focalin XR (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |