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Short Acting Methylphenidate
Short-acting methylphenidate blocks the reuptake of dopamine and norepinephrine in the central nervous system, increasing their availability at the synapse.
Short-acting methylphenidate blocks the reuptake of dopamine and norepinephrine in the central nervous system, increasing their availability at the synapse. Used for Attention-deficit/hyperactivity disorder (ADHD), Narcolepsy.
At a glance
| Generic name | Short Acting Methylphenidate |
|---|---|
| Also known as | • Ritalin, • Ritalina, • Attenta, • Methylin, • Penid |
| Sponsor | BRC Operations Pty. Ltd. |
| Drug class | Sympathomimetic amine; CNS stimulant |
| Target | Dopamine transporter (DAT); Norepinephrine transporter (NET) |
| Modality | Small molecule |
| Therapeutic area | Neurology; Psychiatry |
| Phase | FDA-approved |
Mechanism of action
Methylphenidate is a sympathomimetic amine that inhibits the reuptake transporters (DAT and NET) for dopamine and norepinephrine, leading to increased neurotransmitter concentration in the synaptic cleft. This enhanced dopaminergic and noradrenergic signaling improves attention, focus, and impulse control. The short-acting formulation reaches peak plasma levels within 1–3 hours and has a duration of action of 3–5 hours.
Approved indications
- Attention-deficit/hyperactivity disorder (ADHD)
- Narcolepsy
Common side effects
- Insomnia
- Decreased appetite
- Headache
- Nervousness or anxiety
- Tachycardia
- Abdominal pain
Key clinical trials
- Evaluation of Brain Neurotransmitter Levels in Adults With ADHD, Before and After Stimulant Treatment (NA)
- Brain Connectivity in Attention Deficit Hyperactivity Disorder (ADHD) (NA)
- International Study to Predict Optimised Treatment in Attention Deficit/Hyperactivity Disorder (PHASE4)
Primary sources
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| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |