What are CFTR potentiator drugs?

CFTR potentiator drugs are pharmacologic agents that share a common mechanism (typically targeting CFTR (cystic fibrosis transmembrane conductance regulator)). 3 are currently marketed, with 3 more in clinical development.

What are the marketed CFTR potentiator drugs?

Marketed CFTR potentiator drugs include SUZ, IVA, Ivacaftor (VX-770).

CFTR potentiator

3 marketed 1 in Phase 3 2 in Phase 2

This page covers all CFTR potentiator drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting CFTR (cystic fibrosis transmembrane conductance regulator), CFTR.

Targets

CFTR (cystic fibrosis transmembrane conductance regulator) · CFTR

Marketed (3)

SUZ · Vertex Pharmaceuticals Incorporated · Pulmonary/Respiratory
SUZ is a CFTR potentiator that enhances the function of cystic fibrosis transmembrane conductance regulator protein to improve chloride transport in cystic fibrosis patients.
IVA · Vertex Pharmaceuticals Incorporated · Pulmonary/Respiratory
IVA is a CFTR potentiator that increases the open probability of the cystic fibrosis transmembrane conductance regulator protein to enhance chloride ion transport.
Ivacaftor (VX-770) · University of Alabama at Birmingham · Respiratory / Genetic Disorders
Ivacaftor is a CFTR potentiator that increases the open probability and activity of the cystic fibrosis transmembrane conductance regulator (CFTR) protein at the cell surface.

Phase 3 pipeline (1)

VX-770 · Vertex Pharmaceuticals Incorporated · Respiratory / Genetic Disorders
VX-770 is a CFTR potentiator that increases the opening probability and duration of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel at the cell surface.

Phase 2 pipeline (2)

Elexacaftor-tezacaftor-ivacaftor exposure · Jennifer Taylor-Cousar · Respiratory
CFTR potentiator
Ivacaftor Exposed · Vertex Pharmaceuticals Incorporated · Respiratory
Potentiates CFTR chloride channel function