Cell therapy
This page covers all Cell therapy drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Neurotrophic factors (NGF, BDNF, GDNF).
Targets
Neurotrophic factors (NGF, BDNF, GDNF)
Marketed (8)
- Mesenchymal stromal cells · National Research Center for Hematology, Russia · Immunology, Regenerative Medicine
Mesenchymal stromal cells (MSCs) are bone marrow-derived multipotent cells that exert immunomodulatory and tissue-regenerative effects through paracrine signaling and direct cell-cell interactions. - stem cells infusion · University of Campania Luigi Vanvitelli · Regenerative Medicine
Stem cell infusion delivers undifferentiated or progenitor cells that can differentiate, migrate to damaged tissues, and promote regeneration and immunomodulation. - Stem Cell · Neurogen Brain and Spine Institute · Neurology
Stem cell therapy aims to replace or repair damaged neural tissue by transplanting undifferentiated cells that can differentiate into functional neurons and glial cells. - Mesenchymal Stem Cells (MSCs) · The Cleveland Clinic · Regenerative Medicine, Immunology, Orthopedics
Mesenchymal stem cells exert therapeutic effects through immunomodulation, anti-inflammatory signaling, and tissue repair via paracrine secretion of bioactive factors and direct cell-to-cell interactions. - Fibroblasts and keratinocytes · Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus · Regenerative Medicine / Dermatology
This is a cellular therapy product consisting of cultured fibroblasts and keratinocytes that promote tissue regeneration and wound healing. - Cord Blood Cell · China Spinal Cord Injury Network · Neurology
Cord blood-derived cells promote neural regeneration and functional recovery in spinal cord injury through cell replacement, neuroprotection, and anti-inflammatory effects. - umbilical cord-mesenchymal stem cells · General Hospital of Shenyang Military Region · Regenerative Medicine
Umbilical cord-mesenchymal stem cells promote tissue repair and regeneration through immunomodulation, anti-inflammatory effects, and differentiation into specialized cell types. - RAK therapy · Kaohsiung Medical University Chung-Ho Memorial Hospital · Regenerative Medicine
RAK therapy is a regenerative medicine approach that uses autologous bone marrow-derived cells to promote tissue repair and regeneration.
Phase 3 pipeline (22)
- IDCT (rebonuputemcel) · DiscGenics, Inc. · Orthopedics / Spine
IDCT (rebonuputemcel) is an allogeneic juvenile chondrocyte cell therapy designed to regenerate cartilage and restore joint function in degenerative disc disease. - NurOwn® (MSC-NTF cells) · Brainstorm-Cell Therapeutics · Neurology
NurOwn delivers mesenchymal stem cells engineered to secrete neurotrophic factors that support motor neuron survival and function in amyotrophic lateral sclerosis (ALS). - Autologous BM MSC · Stem Med Pte. Ltd. · Regenerative Medicine
Autologous bone marrow-derived mesenchymal stem cells (BM MSCs) are harvested from the patient's own bone marrow and administered to promote tissue repair and modulate immune responses. - Cultured Mesenchymal Stem Cells · Universidad Autonoma de Madrid · Regenerative Medicine / Immunology
Cultured mesenchymal stem cells promote tissue repair and regeneration through immunomodulation, anti-inflammatory signaling, and differentiation into replacement cells. - Adipose Mesenchymal stem cells · Universidad Catolica Santiago de Guayaquil · Regenerative Medicine
Adipose-derived mesenchymal stem cells promote tissue repair and regeneration through immunomodulation, anti-inflammatory signaling, and differentiation into functional cell types. - Autologous MSCs · Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León · Regenerative Medicine / Orthopedics
Autologous mesenchymal stem cells (MSCs) are harvested from the patient's own bone marrow or adipose tissue and administered to promote tissue repair and modulate immune responses. - Bone Marrow Aspirate Injection · Federal University of São Paulo · Regenerative Medicine
Bone marrow aspirate injection delivers autologous bone marrow-derived cells to promote tissue regeneration and repair through paracrine signaling and stem cell differentiation. - Allogenic MSCs · Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León · Regenerative Medicine / Immunology
Allogeneic mesenchymal stem cells (MSCs) exert immunomodulatory and regenerative effects by secreting anti-inflammatory cytokines and promoting tissue repair. - Human Stem Cells · Celavie Bioscences, LLC · Regenerative Medicine
Human stem cells differentiate and regenerate damaged or diseased tissues by replacing lost cells and secreting therapeutic factors. - Bone marrow mesenchymal stem cells · Federal Research Clinical Center of Federal Medical & Biological Agency, Russia · Regenerative Medicine
Bone marrow mesenchymal stem cells differentiate and engraft into damaged tissues to promote regeneration, reduce inflammation, and restore tissue function. - allogeneic stem cell transplant · University of Wuerzburg · Oncology, Hematology, Immunology
Allogeneic stem cell transplant replaces a patient's diseased or damaged bone marrow with healthy stem cells from a donor to restore normal hematopoietic and immune function. - MultiStem® · Healios K.K. · Immunology, Regenerative Medicine
MultiStem is a cell therapy derived from bone marrow-derived mesenchymal stem cells that modulates immune responses and promotes tissue repair. - Auto-CD34+ cells · Lisata Therapeutics, Inc. · Regenerative Medicine / Cardiovascular
Auto-CD34+ cells are autologous CD34+ hematopoietic stem cells mobilized and collected from a patient's own bone marrow or peripheral blood, then reinfused to promote tissue regeneration and repair. - chondrocyte-alginate gel suspension · FDA Office of Orphan Products Development · Orthopedics
Chondrocyte-alginate gel suspension is a cell-based therapy that delivers chondrocytes to repair damaged cartilage. - Allogenic human purified pancreatic islets · National Institute of Allergy and Infectious Diseases (NIAID) · Endocrinology / Diabetes
Allogenic human purified pancreatic islets restore insulin-producing beta cell function by transplanting functional islet cells into patients with type 1 diabetes. - Autologous cultured keratinocyte cell · Biosolution Co., Ltd. · Dermatology
Autologous cultured keratinocytes are patient-derived skin cells grown in vitro and applied topically or as a graft to promote wound healing and tissue regeneration. - Autologous cell therapy · Dr. Grant M. Pagdin · Regenerative Medicine / Immunology
Autologous cell therapy involves harvesting a patient's own cells, processing or expanding them ex vivo, and reinfusing them to restore function or modulate immune responses. - Autologous Intrathecal Hematopoietic Stem Cells · Hospital Universitario Dr. Jose E. Gonzalez · Neurology
Autologous hematopoietic stem cells are harvested from the patient, processed, and reinfused intrathecally into the cerebrospinal fluid to promote neural repair and regeneration. - Hearticellgram-AMI · Pharmicell Co., Ltd. · Cardiovascular
Hearticellgram-AMI is an autologous bone marrow-derived cell therapy that promotes cardiac regeneration and repair following acute myocardial infarction. - Autologous Menstrual Blood Stem Cells · Avicenna Research Institute · Regenerative Medicine
Autologous menstrual blood-derived stem cells are harvested from a patient's own menstrual fluid and reinfused to promote tissue regeneration and reduce inflammation. - PLX-PAD · Pluristem Ltd. · Regenerative Medicine / Vascular Disease
PLX-PAD is a placental-derived cell therapy that promotes tissue repair and regeneration through anti-inflammatory and pro-angiogenic mechanisms. - Mesenchymal Stem Cells · Ottawa Hospital Research Institute · Regenerative Medicine, Immunology
Mesenchymal stem cells promote tissue repair and modulate immune responses through secretion of anti-inflammatory factors and differentiation into specialized cell types.
Phase 2 pipeline (8)
- CLBS12 · Lisata Therapeutics, Inc. · Cardiovascular
CLBS12 is a cell therapy product that aims to repair or replace damaged heart tissue. - Adipose-Derived Mesenchymal Stem Cells · Steminent Biotherapeutics Inc. · Other
Adipose-derived mesenchymal stem cells modulate immune responses and promote tissue repair through paracrine signaling and differentiation into multiple cell types. - Allogenic Human Islet Cells · City of Hope Medical Center · Diabetes
Allogeneic human islet cells restore insulin-producing capacity by replacing or supplementing the patient's own dysfunctional beta cells. - CLBS03 High Dose · Lisata Therapeutics, Inc. · Cardiovascular
CLBS03 High Dose is a cell therapy that aims to repair or replace damaged heart tissue. - Human Dopaminergic Progenitor Cells · iRegene Therapeutics Co., Ltd. · Neurology
Dopaminergic progenitor cells are thought to replace or repair dopamine-producing neurons in the brain. - Autologous UCB Reinfusion · Joanne Kurtzberg, MD · Immunology, Regenerative Medicine
Autologous umbilical cord blood (UCB) cells are reinfused into patients to promote immune reconstitution and tissue repair. - Ex- vivo cultured adult allogeneic MSCs · Stempeutics Research Pvt Ltd · Regenerative medicine, Orthopedics
Ex- vivo cultured adult allogeneic MSCs are thought to exert their therapeutic effects through paracrine mechanisms, releasing various growth factors and cytokines that promote tissue repair and regeneration. - ALLOB® cells with ceramic scaffold · Bone Therapeutics S.A · Orthopedics
ALLOB cells with ceramic scaffold are a type of cell therapy that uses autologous mesenchymal stem cells to promote bone healing and regeneration.
Phase 1 pipeline (2)
- AST-OPC1 · Lineage Cell Therapeutics, Inc. · Neurology
AST-OPC1 is a human oligodendrocyte progenitor cell therapy that promotes myelination and repair in spinal cord injuries. - Autologous DC Therapy · Diakonos Oncology Corporation · Oncology
Autologous dendritic cells are loaded with tumor antigens to stimulate a patient-specific immune response against cancer cells.