Who are XIAFLEX's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Collagenase Clostridium Histolyticum-Aaes, Injectable clostridial collagenase, Control - Crossover to CCH, Qwo, CCH administration.

How often does this brief refresh?

Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-05-13 · How we verify

XIAFLEX — Competitive Intelligence Brief

XIAFLEX (XIAFLEX) competitive landscape: 5 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Collagenase enzyme. Area: Orthopedics / Rheumatology.

marketed Collagenase enzyme Collagen (types I, II, III, IV, V, VI, VII) Orthopedics / Rheumatology Biologic Live · refreshed every 30 min

Target snapshot

XIAFLEX (XIAFLEX) — Hospital for Special Surgery, New York. Xiaflex is a collagenase that breaks down collagen in fibrotic tissue, allowing mechanical manipulation to improve joint mobility and function.

Comparator set (5 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
XIAFLEX TARGET	XIAFLEX	Hospital for Special Surgery, New York	marketed	Collagenase enzyme	Collagen (types I, II, III, IV, V, VI, VII)
Collagenase Clostridium Histolyticum-Aaes	Collagenase Clostridium Histolyticum-Aaes	Luxurgery	marketed	Collagenase enzyme	Collagen types I and III
Injectable clostridial collagenase	Injectable clostridial collagenase	Indiana Hand to Shoulder Center	marketed	Collagenase enzyme	Collagen (types I and III)
Control - Crossover to CCH	Control - Crossover to CCH	Charitable Union for the Research and Education of Peyronie's Disease	marketed	Collagenase enzyme	Collagen (types I and III)
Qwo	Qwo	DMR Research, PLLC	marketed	Collagenase enzyme	Collagen types I and III
CCH administration	CCH administration	Charitable Union for the Research and Education of Peyronie's Disease	marketed	Collagenase enzyme	Collagen I and III

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Collagenase enzyme class)

Charitable Union for the Research and Education of Peyronie's Disease · 2 drugs in this class
DMR Research, PLLC · 1 drug in this class
Hospital for Special Surgery, New York · 1 drug in this class
Indiana Hand to Shoulder Center · 1 drug in this class
Luxurgery · 1 drug in this class

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Cite this brief

Drug Landscape (2026). XIAFLEX — Competitive Intelligence Brief. https://druglandscape.com/ci/xiaflex. Accessed 2026-05-13.

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