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Collagenase Clostridium Histolyticum-Aaes
Collagenase Clostridium Histolyticum-Aaes is a bacterial enzyme that directly breaks down collagen in connective tissue, allowing mechanical disruption of fibrotic structures.
Collagenase Clostridium Histolyticum-Aaes is a bacterial enzyme that directly breaks down collagen in connective tissue, allowing mechanical disruption of fibrotic structures. Used for Dupuytren's contracture, Peyronie's disease.
At a glance
| Generic name | Collagenase Clostridium Histolyticum-Aaes |
|---|---|
| Also known as | QWO |
| Sponsor | Luxurgery |
| Drug class | Collagenase enzyme |
| Target | Collagen types I and III |
| Modality | Small molecule |
| Therapeutic area | Dermatology / Rheumatology |
| Phase | FDA-approved |
Mechanism of action
This enzyme cleaves collagen types I and III at specific peptide bonds, degrading the structural protein that forms the basis of fibrotic cords and contractures. By enzymatically weakening the collagen matrix, the drug enables subsequent mechanical manipulation or natural remodeling of the affected tissue. This mechanism is particularly useful in conditions where abnormal collagen deposition creates mechanical contractures or fibrotic bands.
Approved indications
- Dupuytren's contracture
- Peyronie's disease
Common side effects
- Injection site pain or swelling
- Bruising or hematoma
- Edema
- Lymphadenopathy
Key clinical trials
- Study of Different Interventions to Reduce Bruising Following CCH-Aaes Treatment for Cellulite of the Buttocks (PHASE2)
- Effect of Oral TXA on Buttock Bruising Post CCH Injections in Adult Females (PHASE4)
- To Assess the Effectiveness of Multiple Dose, Multiple Concentrations of Qwo, for the Treatment of Mild to Moderate Cellulite. (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Collagenase Clostridium Histolyticum-Aaes CI brief — competitive landscape report
- Collagenase Clostridium Histolyticum-Aaes updates RSS · CI watch RSS
- Luxurgery portfolio CI