{"id":"collagenase-clostridium-histolyticum-aaes","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site pain or swelling"},{"rate":null,"effect":"Bruising or hematoma"},{"rate":null,"effect":"Edema"},{"rate":null,"effect":"Lymphadenopathy"}]},"_chembl":{"chemblId":"CHEMBL2108709","moleculeType":"Enzyme"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This enzyme cleaves collagen types I and III at specific peptide bonds, degrading the structural protein that forms the basis of fibrotic cords and contractures. By enzymatically weakening the collagen matrix, the drug enables subsequent mechanical manipulation or natural remodeling of the affected tissue. This mechanism is particularly useful in conditions where abnormal collagen deposition creates mechanical contractures or fibrotic bands.","oneSentence":"Collagenase Clostridium Histolyticum-Aaes is a bacterial enzyme that directly breaks down collagen in connective tissue, allowing mechanical disruption of fibrotic structures.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:43:36.358Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Dupuytren's contracture"},{"name":"Peyronie's disease"}]},"trialDetails":[{"nctId":"NCT05419505","phase":"PHASE2","title":"Study of Different Interventions to Reduce Bruising Following CCH-Aaes Treatment for Cellulite of the Buttocks","status":"COMPLETED","sponsor":"Endo Pharmaceuticals","startDate":"2022-06-15","conditions":"Edematous Fibrosclerotic Panniculopathy, Cellulite","enrollment":91},{"nctId":"NCT05309525","phase":"PHASE4","title":"Effect of Oral TXA on Buttock Bruising Post CCH Injections in Adult Females","status":"COMPLETED","sponsor":"Luxurgery","startDate":"2022-04-22","conditions":"Cellulite","enrollment":17},{"nctId":"NCT05026216","phase":"PHASE4","title":"To Assess the Effectiveness of Multiple Dose, Multiple Concentrations of Qwo, for the Treatment of Mild to Moderate Cellulite.","status":"COMPLETED","sponsor":"DMR Research, PLLC","startDate":"2021-03-29","conditions":"Cellulite","enrollment":5}],"_emaApprovals":[],"_faersSignals":[{"count":1,"reaction":"ANXIETY"},{"count":1,"reaction":"CONTUSION"},{"count":1,"reaction":"ILL-DEFINED DISORDER"},{"count":1,"reaction":"INJECTION SITE BRUISING"},{"count":1,"reaction":"INJECTION SITE DISCOLOURATION"},{"count":1,"reaction":"PAIN"},{"count":1,"reaction":"SKIN ATROPHY"},{"count":1,"reaction":"SKIN DISCOLOURATION"}],"_approvalHistory":[],"publicationCount":13,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["QWO"],"phase":"marketed","status":"active","brandName":"Collagenase Clostridium Histolyticum-Aaes","genericName":"Collagenase Clostridium Histolyticum-Aaes","companyName":"Luxurgery","companyId":"luxurgery","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Collagenase Clostridium Histolyticum-Aaes is a bacterial enzyme that directly breaks down collagen in connective tissue, allowing mechanical disruption of fibrotic structures. Used for Dupuytren's contracture, Peyronie's disease.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}