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Qwo
Qwo is a mixture of collagenase clostridium histolyticum enzymes that enzymatically breaks down collagen in subcutaneous tissue to reduce the appearance of cellulite.
Qwo is a mixture of collagenase clostridium histolyticum enzymes that enzymatically breaks down collagen in subcutaneous tissue to reduce the appearance of cellulite. Used for Cellulite in women of reproductive age.
At a glance
| Generic name | Qwo |
|---|---|
| Sponsor | DMR Research, PLLC |
| Drug class | Collagenase enzyme |
| Target | Collagen types I and III |
| Modality | Small molecule |
| Therapeutic area | Dermatology |
| Phase | FDA-approved |
Mechanism of action
Qwo contains two purified collagenase enzymes derived from Clostridium histolyticum that directly cleave collagen types I and III in the dermal and subcutaneous layers. By degrading the structural collagen that contributes to the dimpled appearance of cellulite, the treatment reduces cellulite severity. The enzymes work locally at the injection site to remodel the fibrous septae responsible for the characteristic cellulite appearance.
Approved indications
- Cellulite in women of reproductive age
Common side effects
- Bruising
- Pain at injection site
- Swelling
- Nodule formation
- Erythema
Key clinical trials
- Study of Different Interventions to Reduce Bruising Following CCH-Aaes Treatment for Cellulite of the Buttocks (PHASE2)
- Long-Term Study of EN3835 (CCH-aaes) in Edematous Fibrosclerotic Panniculopathy (Cellulite) (PHASE3)
- Effects of Mitigation Treatments on Bruising of CCH-aaes Treatment of Buttock Cellulite (PHASE4)
- Effect of Oral TXA on Buttock Bruising Post CCH Injections in Adult Females (PHASE4)
- To Assess the Effectiveness of Multiple Dose, Multiple Concentrations of Qwo, for the Treatment of Mild to Moderate Cellulite. (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Qwo CI brief — competitive landscape report
- Qwo updates RSS · CI watch RSS
- DMR Research, PLLC portfolio CI