{"id":"qwo","safety":{"commonSideEffects":[{"rate":"71","effect":"Bruising"},{"rate":"65","effect":"Pain at injection site"},{"rate":"61","effect":"Swelling"},{"rate":"25","effect":"Nodule formation"},{"rate":"20","effect":"Erythema"}]},"_chembl":{"chemblId":"CHEMBL2108709","moleculeType":"Enzyme"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Qwo contains two purified collagenase enzymes derived from Clostridium histolyticum that directly cleave collagen types I and III in the dermal and subcutaneous layers. By degrading the structural collagen that contributes to the dimpled appearance of cellulite, the treatment reduces cellulite severity. The enzymes work locally at the injection site to remodel the fibrous septae responsible for the characteristic cellulite appearance.","oneSentence":"Qwo is a mixture of collagenase clostridium histolyticum enzymes that enzymatically breaks down collagen in subcutaneous tissue to reduce the appearance of cellulite.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:03:30.567Z","_scrapedBy":"cloudflare-swarm","_wikipedia":{"url":"https://en.wikipedia.org/wiki/Collagenase_clostridium_histolyticum","title":"Collagenase clostridium histolyticum","extract":"Collagenase clostridium histolyticum is an enzyme produced by the bacterium Clostridium histolyticum that dismantles collagen. It is used as a powder-and-solvent injection kit for the treatment of Dupuytren's contracture, a condition where the fingers bend towards the palm and cannot be fully straightened, and Peyronie's disease, a connective tissue disorder involving the growth of fibrous plaques in the soft tissue of the penis. BioSpecifics Technologies developed the preparation, which is manufactured and marketed by Endo Pharmaceuticals as Xiaflex in the US and by Sobi as Xiapex in Europe."},"indications":{"approved":[{"name":"Cellulite in women of reproductive age"}]},"trialDetails":[{"nctId":"NCT05419505","phase":"PHASE2","title":"Study of Different Interventions to Reduce Bruising Following CCH-Aaes Treatment for Cellulite of the Buttocks","status":"COMPLETED","sponsor":"Endo Pharmaceuticals","startDate":"2022-06-15","conditions":"Edematous Fibrosclerotic Panniculopathy, Cellulite","enrollment":91},{"nctId":"NCT03526549","phase":"PHASE3","title":"Long-Term Study of EN3835 (CCH-aaes) in Edematous Fibrosclerotic Panniculopathy (Cellulite)","status":"COMPLETED","sponsor":"Endo Pharmaceuticals","startDate":"2018-04-26","conditions":"Edematous Fibrosclerotic Panniculopathy, Cellulite","enrollment":483},{"nctId":"NCT04677712","phase":"PHASE4","title":"Effects of Mitigation Treatments on Bruising of CCH-aaes Treatment of Buttock Cellulite","status":"COMPLETED","sponsor":"Endo Pharmaceuticals","startDate":"2020-12-28","conditions":"Edematous Fibrosclerotic Panniculopathy (EFP), Cellulite","enrollment":48},{"nctId":"NCT05309525","phase":"PHASE4","title":"Effect of Oral TXA on Buttock Bruising Post CCH Injections in Adult Females","status":"COMPLETED","sponsor":"Luxurgery","startDate":"2022-04-22","conditions":"Cellulite","enrollment":17},{"nctId":"NCT05026216","phase":"PHASE4","title":"To Assess the Effectiveness of Multiple Dose, Multiple Concentrations of Qwo, for the Treatment of Mild to Moderate Cellulite.","status":"COMPLETED","sponsor":"DMR Research, PLLC","startDate":"2021-03-29","conditions":"Cellulite","enrollment":5}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":4,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Qwo","genericName":"Qwo","companyName":"DMR Research, PLLC","companyId":"dmr-research-pllc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Qwo is a mixture of collagenase clostridium histolyticum enzymes that enzymatically breaks down collagen in subcutaneous tissue to reduce the appearance of cellulite. Used for Cellulite in women of reproductive age.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}