Who are VX-661/Ivacaftor's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Symdeko (Copackaged), Ivacaftor (VX-770), Ivacaftor/Ataluren, LUM/IVA, Ivacaftor and Symdeko, IVA.

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Last reviewed 2026-05-16 · How we verify

VX-661/Ivacaftor — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

VX-661/Ivacaftor (VX-661/Ivacaftor) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: CFTR corrector. Area: Respiratory.

phase 3 CFTR corrector CFTR Respiratory Small molecule Live · refreshed every 30 min

Target snapshot

VX-661/Ivacaftor (VX-661/Ivacaftor) — Vertex Pharmaceuticals Incorporated. VX-661/Ivacaftor is a cystic fibrosis transmembrane conductance regulator (CFTR) corrector.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
VX-661/Ivacaftor TARGET	VX-661/Ivacaftor	Vertex Pharmaceuticals Incorporated	phase 3	CFTR corrector	CFTR
Symdeko (Copackaged)	TEZACAFTOR	Vertex Pharms	marketed		CFTR	2018-01-01
Ivacaftor (VX-770)	Ivacaftor (VX-770)	University of Alabama at Birmingham	marketed	CFTR potentiator	CFTR (cystic fibrosis transmembrane conductance regulator)
Ivacaftor/Ataluren	Ivacaftor/Ataluren	University of Alabama at Birmingham	marketed	CFTR modulator combination	CFTR (Cystic Fibrosis Transmembrane Conductance Regulator)
LUM/IVA	LUM/IVA	Vertex Pharmaceuticals Incorporated	marketed	CFTR modulator combination (corrector + potentiator)	CFTR (cystic fibrosis transmembrane conductance regulator)
Ivacaftor and Symdeko	Ivacaftor and Symdeko	University of Alabama at Birmingham	marketed	CFTR modulator (potentiator and corrector combination)	CFTR (Cystic Fibrosis Transmembrane Conductance Regulator)
IVA	IVA	Vertex Pharmaceuticals Incorporated	marketed	CFTR potentiator	CFTR (cystic fibrosis transmembrane conductance regulator)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

2026-07-06 — Symdeko (Copackaged) · 8354427 · US
2026-12-28 — Symdeko (Copackaged) · 9931334 · US
2026-12-28 — Symdeko (Copackaged) · 9670163 · US
2026-12-28 — Symdeko (Copackaged) · 8754224 · US
2026-12-28 — Symdeko (Copackaged) · 8410274 · US
2027-04-09 — Symdeko (Copackaged) · 10239867 · US
2027-04-09 — Symdeko (Copackaged) · 9974781 · US
2027-04-09 — Symdeko (Copackaged) · 11639347 · US
2027-04-09 — Symdeko (Copackaged) · 10022352 · US
2027-05-01 — Symdeko (Copackaged) · 8598181 · US
2027-05-01 — Symdeko (Copackaged) · 7645789 · US
2027-05-01 — Symdeko (Copackaged) · 8623905 · US
2027-05-20 — Symdeko (Copackaged) · 7495103 · US
2027-06-03 — Symdeko (Copackaged) · 7776905 · US
2027-08-05 — Symdeko (Copackaged) · 8324242 · US
2027-11-12 — Symdeko (Copackaged) · 8415387 · US
2029-08-13 — Symdeko (Copackaged) · 11564916 · US
2029-08-13 — Symdeko (Copackaged) · 10646481 · US
2031-03-25 — Symdeko (Copackaged) · 10081621 · US
2031-03-25 — Symdeko (Copackaged) · 11578062 · US
2033-07-15 — Symdeko (Copackaged) · 10058546 · US
2033-07-15 — Symdeko (Copackaged) · 9012496 · US
2035-04-14 — Symdeko (Copackaged) · 10206877 · US

Sponsor landscape (CFTR corrector class)

Vertex Pharmaceuticals Incorporated · 3 drugs in this class
Chiesi Farmaceutici S.p.A. · 1 drug in this class
Renovion, Inc. · 1 drug in this class

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Cite this brief

Drug Landscape (2026). VX-661/Ivacaftor — Competitive Intelligence Brief. https://druglandscape.com/ci/vx-661-ivacaftor. Accessed 2026-05-16.

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