Who are VNZ/TEZ/D-IVA's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Symdeko (Copackaged), Ivacaftor (VX-770), Initiation of CFTR Modulator, Ivacaftor/Ataluren, TEZ, Ivacaftor and Symdeko.

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Last reviewed 2026-05-16 · How we verify

VNZ/TEZ/D-IVA — Competitive Intelligence Brief

VNZ/TEZ/D-IVA (VNZ/TEZ/D-IVA) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: CFTR modulator. Area: Cystic Fibrosis.

phase 3 CFTR modulator CFTR Cystic Fibrosis Small molecule Live · refreshed every 30 min

Target snapshot

VNZ/TEZ/D-IVA (VNZ/TEZ/D-IVA) — Vertex Pharmaceuticals Incorporated. VNZ/TEZ/D-IVA is a triple combination therapy consisting of a cystic fibrosis transmembrane conductance regulator (CFTR) modulator, a corrector, and a potentiator.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
VNZ/TEZ/D-IVA TARGET	VNZ/TEZ/D-IVA	Vertex Pharmaceuticals Incorporated	phase 3	CFTR modulator	CFTR
Symdeko (Copackaged)	TEZACAFTOR	Vertex Pharms	marketed		CFTR	2018-01-01
Ivacaftor (VX-770)	Ivacaftor (VX-770)	University of Alabama at Birmingham	marketed	CFTR potentiator	CFTR (cystic fibrosis transmembrane conductance regulator)
Initiation of CFTR Modulator	Initiation of CFTR Modulator	Children's Hospital Medical Center, Cincinnati	marketed	CFTR modulator	CFTR (cystic fibrosis transmembrane conductance regulator)
Ivacaftor/Ataluren	Ivacaftor/Ataluren	University of Alabama at Birmingham	marketed	CFTR modulator combination	CFTR (Cystic Fibrosis Transmembrane Conductance Regulator)
TEZ	TEZ	Vertex Pharmaceuticals Incorporated	marketed	CFTR corrector	CFTR (cystic fibrosis transmembrane conductance regulator)
Ivacaftor and Symdeko	Ivacaftor and Symdeko	University of Alabama at Birmingham	marketed	CFTR modulator (potentiator and corrector combination)	CFTR (Cystic Fibrosis Transmembrane Conductance Regulator)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

2026-07-06 — Symdeko (Copackaged) · 8354427 · US
2026-12-28 — Symdeko (Copackaged) · 9931334 · US
2026-12-28 — Symdeko (Copackaged) · 9670163 · US
2026-12-28 — Symdeko (Copackaged) · 8754224 · US
2026-12-28 — Symdeko (Copackaged) · 8410274 · US
2027-04-09 — Symdeko (Copackaged) · 10239867 · US
2027-04-09 — Symdeko (Copackaged) · 9974781 · US
2027-04-09 — Symdeko (Copackaged) · 11639347 · US
2027-04-09 — Symdeko (Copackaged) · 10022352 · US
2027-05-01 — Symdeko (Copackaged) · 8598181 · US
2027-05-01 — Symdeko (Copackaged) · 7645789 · US
2027-05-01 — Symdeko (Copackaged) · 8623905 · US
2027-05-20 — Symdeko (Copackaged) · 7495103 · US
2027-06-03 — Symdeko (Copackaged) · 7776905 · US
2027-08-05 — Symdeko (Copackaged) · 8324242 · US
2027-11-12 — Symdeko (Copackaged) · 8415387 · US
2029-08-13 — Symdeko (Copackaged) · 11564916 · US
2029-08-13 — Symdeko (Copackaged) · 10646481 · US
2031-03-25 — Symdeko (Copackaged) · 10081621 · US
2031-03-25 — Symdeko (Copackaged) · 11578062 · US
2033-07-15 — Symdeko (Copackaged) · 10058546 · US
2033-07-15 — Symdeko (Copackaged) · 9012496 · US
2035-04-14 — Symdeko (Copackaged) · 10206877 · US

Sponsor landscape (CFTR modulator class)

Vertex Pharmaceuticals Incorporated · 5 drugs in this class
Chiesi Farmaceutici S.p.A. · 1 drug in this class
Children's Hospital Medical Center, Cincinnati · 1 drug in this class
Hospices Civils de Lyon · 1 drug in this class

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Cite this brief

Drug Landscape (2026). VNZ/TEZ/D-IVA — Competitive Intelligence Brief. https://druglandscape.com/ci/vnz-tez-d-iva. Accessed 2026-05-16.

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