Topical NO — Competitive Intelligence Brief

Topical NO (Topical NO) competitive landscape: 4 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Nitric oxide donor. Area: Dermatology; Wound Care.

marketed Nitric oxide donor Nitric oxide pathway; soluble guanylate cyclase Dermatology; Wound Care Small molecule

Target snapshot

Topical NO (Topical NO) — University of Aberdeen. Topical NO is a nitric oxide-releasing formulation applied to the skin that promotes wound healing and tissue repair through vasodilation and antimicrobial effects.

Comparator set (4 drugs)

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Topical NO TARGET	Topical NO	University of Aberdeen	marketed	Nitric oxide donor	Nitric oxide pathway; soluble guanylate cyclase
nitrate rich beetroot juice	nitrate rich beetroot juice	Penn State University	phase 3	Dietary nitrate supplement	Nitric oxide pathway; soluble guanylate cyclase
L-arginine + heme arginate	L-arginine + heme arginate	Radboud University Medical Center	marketed	Amino acid supplement / Nitric oxide donor	Nitric oxide synthase (NOS); hemoglobin
Heme arginate + L-arginine	Heme arginate + L-arginine	Radboud University Medical Center	marketed	Heme replacement therapy with nitric oxide donor	ALA synthase (indirect inhibition via heme feedback); nitric oxide synthase (L-arginine substrate)
Oral L-arginine aspartate administration	Oral L-arginine aspartate administration	Ukrainian Medical Stomatological Academy	phase 3	Amino acid supplement / Nitric oxide donor	Nitric oxide synthase (NOS)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Nitric oxide donor class)

1. University of Aberdeen · 1 drug in this class