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L-arginine + heme arginate
L-arginine and heme arginate work together to restore nitric oxide production and improve vascular function in patients with arginine deficiency or endothelial dysfunction.
L-arginine and heme arginate work together to restore nitric oxide production and improve vascular function in patients with arginine deficiency or endothelial dysfunction. Used for Sepsis-associated microvascular dysfunction, Arginine deficiency states, Endothelial dysfunction in critical illness.
At a glance
| Generic name | L-arginine + heme arginate |
|---|---|
| Sponsor | Radboud University Medical Center |
| Drug class | Amino acid supplement / Nitric oxide donor |
| Target | Nitric oxide synthase (NOS); hemoglobin |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular; Critical Care; Metabolic Disorders |
| Phase | FDA-approved |
Mechanism of action
L-arginine is a semi-essential amino acid that serves as a substrate for nitric oxide synthase, enabling the production of nitric oxide, a critical vasodilator and signaling molecule. Heme arginate (also known as arginate heme) provides heme groups that support hemoglobin function and may enhance oxygen delivery. Together, these agents aim to restore endothelial function and improve microvascular perfusion in conditions characterized by arginine depletion or nitric oxide deficiency.
Approved indications
- Sepsis-associated microvascular dysfunction
- Arginine deficiency states
- Endothelial dysfunction in critical illness
Common side effects
- Gastrointestinal disturbance
- Hyperkalemia
- Nausea
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- L-arginine + heme arginate CI brief — competitive landscape report
- L-arginine + heme arginate updates RSS · CI watch RSS
- Radboud University Medical Center portfolio CI