{"id":"l-arginine-heme-arginate","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal disturbance"},{"rate":null,"effect":"Hyperkalemia"},{"rate":null,"effect":"Nausea"}]},"_chembl":{"chemblId":"CHEMBL4297285","moleculeType":"Small molecule","molecularWeight":"792.72"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"L-arginine is a semi-essential amino acid that serves as a substrate for nitric oxide synthase, enabling the production of nitric oxide, a critical vasodilator and signaling molecule. Heme arginate (also known as arginate heme) provides heme groups that support hemoglobin function and may enhance oxygen delivery. Together, these agents aim to restore endothelial function and improve microvascular perfusion in conditions characterized by arginine depletion or nitric oxide deficiency.","oneSentence":"L-arginine and heme arginate work together to restore nitric oxide production and improve vascular function in patients with arginine deficiency or endothelial dysfunction.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:51:13.311Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Sepsis-associated microvascular dysfunction"},{"name":"Arginine deficiency states"},{"name":"Endothelial dysfunction in critical illness"}]},"trialDetails":[{"nctId":"NCT00856817","phase":"PHASE4","title":"Heme Oxygenase (HO) Activity and Adenosine Induced Vasodilation","status":"TERMINATED","sponsor":"Radboud University Medical Center","startDate":"2009-03","conditions":"Atherosclerotic Cardiovascular Disease","enrollment":6}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":53,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"L-arginine + heme arginate","genericName":"L-arginine + heme arginate","companyName":"Radboud University Medical Center","companyId":"radboud-university-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"L-arginine and heme arginate work together to restore nitric oxide production and improve vascular function in patients with arginine deficiency or endothelial dysfunction. Used for Sepsis-associated microvascular dysfunction, Arginine deficiency states, Endothelial dysfunction in critical illness.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}