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nitrate rich beetroot juice
Nitrate-rich beetroot juice increases nitric oxide bioavailability through dietary nitrate conversion, promoting vasodilation and improving blood flow.
Nitrate-rich beetroot juice increases nitric oxide bioavailability through dietary nitrate conversion, promoting vasodilation and improving blood flow. Used for Hypertension management, Endothelial dysfunction, Exercise performance enhancement.
At a glance
| Generic name | nitrate rich beetroot juice |
|---|---|
| Also known as | Beet-It Organic Shot |
| Sponsor | Penn State University |
| Drug class | Dietary nitrate supplement |
| Target | Nitric oxide pathway; soluble guanylate cyclase |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | Phase 3 |
Mechanism of action
Beetroot juice contains high concentrations of inorganic nitrates that are converted to nitrite by oral bacteria and subsequently to nitric oxide (NO) in the bloodstream. Nitric oxide acts as a potent vasodilator, relaxing vascular smooth muscle and reducing blood pressure. This mechanism improves endothelial function and enhances oxygen delivery to tissues, particularly benefiting cardiovascular and exercise performance.
Approved indications
- Hypertension management
- Endothelial dysfunction
- Exercise performance enhancement
- Cardiovascular disease prevention
Common side effects
- Beeturia (red urine discoloration)
- Gastrointestinal upset
- Headache
- Dizziness
Key clinical trials
- Beetroot Juice: A Natural Boost for Cardiovascular Health in Postmenopausal Women? (NA)
- Inorganic Nitrates in Intermediate High-risk Pulmonary Embolism (NA)
- Effect of Dietary Nitrate on Immobilization-induced Changes in Skeletal Muscle in Young Healthy Men (NA)
- Targeting Neurovascular Coupling in Cognitive Decline Via Nitrate-Based Supplementation (NA)
- Effects of Dietary Nitrate in Women With Secondary Amenorrhea (NA)
- The Effects of Nitrate, Caffeine, and Cold Exposure on Cardiovascular Function. (NA)
- Interaction Between Inorganic Nitrate Supplementation and Metformin in Individuals With Prediabetes (NA)
- Improving Mobility After Revascularization in Peripheral Artery Disease (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |