Who are St. John's Wort extract's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): ginsenoside RE, bee venom, Bergamot Oil, thyme honey mouth rinse, Liposomal curcumin, Manuka honey.

How often does this brief refresh?

Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-06-10 · How we verify

St. John's Wort extract — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

St. John's Wort extract (St. John's Wort extract) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: natural product. Area: Psychiatry.

phase 3 natural product Psychiatry Small molecule Live · refreshed every 30 min

Target snapshot

St. John's Wort extract (St. John's Wort extract) — Cassella-med GmbH & Co. KG. St. John's Wort extract acts as a natural antidepressant by increasing levels of neurotransmitters like serotonin, dopamine, and norepinephrine in the brain.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
St. John's Wort extract TARGET	St. John's Wort extract	Cassella-med GmbH & Co. KG	phase 3	natural product
ginsenoside RE	ginsenoside RE	Washington University School of Medicine	marketed	Natural product/herbal extract
bee venom	bee venom	Assistance Publique - Hôpitaux de Paris	marketed	Natural product immunomodulator
Bergamot Oil	Bergamot Oil	Wake Forest University Health Sciences	marketed	Natural product / Botanical extract	HMG-CoA reductase, PPAR-α, PPAR-γ, LDL receptor
thyme honey mouth rinse	thyme honey mouth rinse	Ain Shams University	marketed	Herbal/natural product mouth rinse
Liposomal curcumin	Liposomal curcumin	University of Florida	marketed	Natural product derivative; anti-inflammatory/antioxidant agent
Manuka honey	Manuka honey	University of Zagreb	marketed	Natural product / Topical antimicrobial agent

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (natural product class)

Cassella-med GmbH & Co. KG · 1 drug in this class

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Cite this brief

Drug Landscape (2026). St. John's Wort extract — Competitive Intelligence Brief. https://druglandscape.com/ci/st-john-s-wort-extract. Accessed 2026-06-10.

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Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing