Who are Protamine ratio dose's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Protamine fixed dose, Protamin administration, PO continuous infusion of Protamine.

How often does this brief refresh?

Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-05-14 · How we verify

Protamine ratio dose — Competitive Intelligence Brief

Protamine ratio dose (Protamine ratio dose) competitive landscape: 3 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Heparin antagonist / Anticoagulant reversal agent. Area: Cardiovascular / Hemostasis.

marketed Heparin antagonist / Anticoagulant reversal agent Heparin (unfractionated and low-molecular-weight heparin) Cardiovascular / Hemostasis Small molecule Live · refreshed every 30 min

Target snapshot

Protamine ratio dose (Protamine ratio dose) — University of Miami. Protamine is a positively charged protein that binds to and neutralizes the anticoagulant effects of heparin by forming an inactive complex.

Comparator set (3 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
Protamine ratio dose TARGET	Protamine ratio dose	University of Miami	marketed	Heparin antagonist / Anticoagulant reversal agent	Heparin (unfractionated and low-molecular-weight heparin)
Protamine fixed dose	Protamine fixed dose	University of Miami	marketed	Heparin antagonist / Anticoagulant reversal agent	Heparin (unfractionated heparin)
Protamin administration	Protamin administration	University Hospital, Strasbourg, France	marketed	Heparin antagonist / Anticoagulant reversal agent	Heparin (unfractionated heparin)
PO continuous infusion of Protamine	PO continuous infusion of Protamine	SANE-Society of Anesthesiology	marketed	Heparin antagonist / Anticoagulant reversal agent	Heparin (unfractionated and low-molecular-weight heparin)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Heparin antagonist / Anticoagulant reversal agent class)

University of Miami · 2 drugs in this class
SANE-Society of Anesthesiology · 1 drug in this class
University Hospital, Strasbourg, France · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Protamine ratio dose — Competitive Intelligence Brief. https://druglandscape.com/ci/protamine-ratio-dose. Accessed 2026-05-14.

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