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Protamin administration
Protamine is a positively charged protein that binds to and neutralizes the anticoagulant effects of heparin by forming an inactive complex.
Protamine is a positively charged protein that binds to and neutralizes the anticoagulant effects of heparin by forming an inactive complex. Used for Reversal of heparin anticoagulation following cardiac surgery or invasive procedures, Treatment of heparin overdose.
At a glance
| Generic name | Protamin administration |
|---|---|
| Sponsor | University Hospital, Strasbourg, France |
| Drug class | Heparin antagonist / Anticoagulant reversal agent |
| Target | Heparin (unfractionated heparin) |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular / Hemostasis |
| Phase | FDA-approved |
Mechanism of action
Protamine sulfate is a cationic polypeptide derived from fish sperm that rapidly binds to negatively charged heparin molecules, forming a stable salt complex that is devoid of anticoagulant activity. This reversal of heparin's anticoagulant effect occurs within minutes of intravenous administration. Protamine is used clinically to counteract heparin overdose or to reverse heparin anticoagulation at the end of cardiac surgery or other procedures.
Approved indications
- Reversal of heparin anticoagulation following cardiac surgery or invasive procedures
- Treatment of heparin overdose
Common side effects
- Hypotension
- Bradycardia
- Dyspnea
- Flushing
- Anaphylaxis (rare)
Key clinical trials
- Heparin Based on Ideal Body Weight for Cardiopulmonary Bypass in Obese Patients (PHASE4)
- Heparin Reversal With Two Different Protamine Ratios After Cardiopulmonary By-pass. (NA)
- The Efficacy of Hypertonic Lactate Solution in CABG(Coronary Artery Bypass Grafting) Patients (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Protamin administration CI brief — competitive landscape report
- Protamin administration updates RSS · CI watch RSS
- University Hospital, Strasbourg, France portfolio CI