{"id":"protamin-administration","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Dyspnea"},{"rate":null,"effect":"Flushing"},{"rate":null,"effect":"Anaphylaxis (rare)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Protamine sulfate is a cationic polypeptide derived from fish sperm that rapidly binds to negatively charged heparin molecules, forming a stable salt complex that is devoid of anticoagulant activity. This reversal of heparin's anticoagulant effect occurs within minutes of intravenous administration. Protamine is used clinically to counteract heparin overdose or to reverse heparin anticoagulation at the end of cardiac surgery or other procedures.","oneSentence":"Protamine is a positively charged protein that binds to and neutralizes the anticoagulant effects of heparin by forming an inactive complex.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:36:45.696Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Reversal of heparin anticoagulation following cardiac surgery or invasive procedures"},{"name":"Treatment of heparin overdose"}]},"trialDetails":[{"nctId":"NCT02675647","phase":"PHASE4","title":"Heparin Based on Ideal Body Weight for Cardiopulmonary Bypass in Obese Patients","status":"COMPLETED","sponsor":"University Hospital, Strasbourg, France","startDate":"2015-12","conditions":"Cardiac Surgery, Cardiopulmonary Bypass, Obese Patients (BMI ≥ 30 kg/m²)","enrollment":60},{"nctId":"NCT06154018","phase":"NA","title":"Heparin Reversal With Two Different Protamine Ratios After Cardiopulmonary By-pass.","status":"COMPLETED","sponsor":"University of Ioannina","startDate":"2023-03-18","conditions":"Cardiac Surgery, CAD, Valve Heart Disease","enrollment":98},{"nctId":"NCT00529711","phase":"PHASE3","title":"The Efficacy of Hypertonic Lactate Solution in CABG(Coronary Artery Bypass Grafting) Patients","status":"COMPLETED","sponsor":"Innogene Kalbiotech Pte. Ltd","startDate":"2005-07","conditions":"Low Cardiac Output","enrollment":66}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":6,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Protamin administration","genericName":"Protamin administration","companyName":"University Hospital, Strasbourg, France","companyId":"university-hospital-strasbourg-france","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Protamine is a positively charged protein that binds to and neutralizes the anticoagulant effects of heparin by forming an inactive complex. Used for Reversal of heparin anticoagulation following cardiac surgery or invasive procedures, Treatment of heparin overdose.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}