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PO continuous infusion of Protamine
Protamine is a positively charged protein that binds to and neutralizes the anticoagulant effects of heparin by forming an inactive complex.
Protamine is a positively charged protein that binds to and neutralizes the anticoagulant effects of heparin by forming an inactive complex. Used for Reversal of heparin anticoagulation following cardiac surgery or percutaneous coronary intervention, Management of heparin overdose.
At a glance
| Generic name | PO continuous infusion of Protamine |
|---|---|
| Sponsor | SANE-Society of Anesthesiology |
| Drug class | Heparin antagonist / Anticoagulant reversal agent |
| Target | Heparin (unfractionated and low-molecular-weight heparin) |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular / Hemostasis |
| Phase | FDA-approved |
Mechanism of action
Protamine sulfate is a basic polypeptide derived from fish sperm that rapidly binds to negatively charged heparin molecules, forming a stable salt complex that is devoid of anticoagulant activity. This reversal of heparin's anticoagulant effect occurs within minutes of administration. Continuous infusion allows for titrated reversal and reduces the risk of rebound anticoagulation.
Approved indications
- Reversal of heparin anticoagulation following cardiac surgery or percutaneous coronary intervention
- Management of heparin overdose
Common side effects
- Hypotension
- Bradycardia
- Dyspnea
- Flushing
- Transient thrombocytopenia
- Anaphylaxis (rare)
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |