{"id":"po-continuous-infusion-of-protamine","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Dyspnea"},{"rate":null,"effect":"Flushing"},{"rate":null,"effect":"Transient thrombocytopenia"},{"rate":null,"effect":"Anaphylaxis (rare)"}]},"_chembl":{"chemblId":"CHEMBL1201651","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Protamine sulfate is a basic polypeptide derived from fish sperm that rapidly binds to negatively charged heparin molecules, forming a stable salt complex that is devoid of anticoagulant activity. This reversal of heparin's anticoagulant effect occurs within minutes of administration. Continuous infusion allows for titrated reversal and reduces the risk of rebound anticoagulation.","oneSentence":"Protamine is a positively charged protein that binds to and neutralizes the anticoagulant effects of heparin by forming an inactive complex.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:01:49.853Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Reversal of heparin anticoagulation following cardiac surgery or percutaneous coronary intervention"},{"name":"Management of heparin overdose"}]},"trialDetails":[{"nctId":"NCT01267487","phase":"PHASE4","title":"Clinical Trial Comparing Heparin and Protamine Fixed and Titrated Doses in Cardiac Surgery With Cardiopulmonary Bypass","status":"COMPLETED","sponsor":"SANE-Society of Anesthesiology","startDate":"2009-07","conditions":"Cardiac Surgery, Cardiopulmonary Bypass, Anticoagulation","enrollment":240}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"PO continuous infusion of Protamine","genericName":"PO continuous infusion of Protamine","companyName":"SANE-Society of Anesthesiology","companyId":"sane-society-of-anesthesiology","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Protamine is a positively charged protein that binds to and neutralizes the anticoagulant effects of heparin by forming an inactive complex. Used for Reversal of heparin anticoagulation following cardiac surgery or percutaneous coronary intervention, Management of heparin overdose.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}