Who are preservative-free 0.15% HA's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Nature's Tears, dextran and hypromellose, Retaine™, Cationorm single-dose eye drop, Refresh Relieva PF, Sodium Hyaluronate.

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Last reviewed 2026-05-16 · How we verify

preservative-free 0.15% HA — Competitive Intelligence Brief

preservative-free 0.15% HA (preservative-free 0.15% HA) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Artificial tear / ocular lubricant. Area: Ophthalmology.

marketed Artificial tear / ocular lubricant Ophthalmology Small molecule Live · refreshed every 30 min

Target snapshot

preservative-free 0.15% HA (preservative-free 0.15% HA) — Chang Gung Memorial Hospital. Hyaluronic acid (HA) lubricates and protects the ocular surface by mimicking natural tear film components.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class
preservative-free 0.15% HA TARGET	preservative-free 0.15% HA	Chang Gung Memorial Hospital	marketed	Artificial tear / ocular lubricant
Nature's Tears	Nature's Tears	Aultman Health Foundation	marketed	Artificial tear / Ocular lubricant
dextran and hypromellose	dextran and hypromellose	University of Campinas, Brazil	marketed	Artificial tear / Ocular lubricant
Retaine™	Retaine™	Ocusoft, Inc.	marketed	Artificial tear / ocular lubricant
Cationorm single-dose eye drop	Cationorm single-dose eye drop	Nguyen Viet Giap	marketed	Artificial tear / ocular lubricant
Refresh Relieva PF	Refresh Relieva PF	University of California, Berkeley	marketed	Artificial tear / Ocular lubricant
Sodium Hyaluronate	Sodium Hyaluronate	Tianjin Eye Hospital	marketed	Artificial tear / ocular lubricant

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Artificial tear / ocular lubricant class)

Allergan · 2 drugs in this class
Chang Gung Memorial Hospital · 1 drug in this class
Guang'anmen Hospital of China Academy of Chinese Medical Sciences · 1 drug in this class
Medical University of Vienna · 1 drug in this class
Nguyen Viet Giap · 1 drug in this class
ORA, Inc. · 1 drug in this class
Ocusoft, Inc. · 1 drug in this class
The Mentholatum Company · 1 drug in this class
Tianjin Eye Hospital · 1 drug in this class
University of Sao Paulo · 1 drug in this class

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Cite this brief

Drug Landscape (2026). preservative-free 0.15% HA — Competitive Intelligence Brief. https://druglandscape.com/ci/preservative-free-0-15-ha. Accessed 2026-05-16.

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