Who are Period B's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Rozerem, Actitan F, meloset (melatonin), Melatonin PR, Oral Bedtime Melatonin, Sublingual Melatonin.

How often does this brief refresh?

Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

How do I get this as a recurring report?

Subscribe to /feed/ci/period-b.xml in any RSS reader (Feedly, Inoreader, NewsBlur). Every regulatory action, trial readout, or patent event lands in your feed automatically.

Last reviewed 2026-05-13 · How we verify

Period B — Competitive Intelligence Brief

Period B (Period B) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: melatonin receptor agonist. Area: Sleep disorders.

marketed melatonin receptor agonist MT1/MT2 melatonin receptor Sleep disorders Small molecule Live · refreshed every 30 min

Target snapshot

Period B (Period B) — Apnimed. Period B is a melatonin receptor agonist that helps regulate sleep-wake cycles.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Period B TARGET	Period B	Apnimed	marketed	melatonin receptor agonist	MT1/MT2 melatonin receptor
Rozerem	RAMELTEON	Takeda	marketed	Melatonin Receptor Agonist [EPC]	Melatonin receptor type 1A	2005-01-01
Actitan F	Actitan F	Federico II University	marketed	melatonin receptor agonist	MT1/MT2
meloset (melatonin)	meloset (melatonin)	B.P. Koirala Institute of Health Sciences	marketed	Melatonin receptor agonist	MT1 and MT2 receptors
Melatonin PR	Melatonin PR	Seoul National University Hospital	marketed	Melatonin receptor agonist	MT1 and MT2 melatonin receptors
Oral Bedtime Melatonin	Oral Bedtime Melatonin	Hospital San Carlos, Madrid	marketed	Melatonin receptor agonist	MT1 and MT2 melatonin receptors
Sublingual Melatonin	Sublingual Melatonin	Al-Azhar University	marketed	Melatonin receptor agonist	MT1 and MT2 melatonin receptors

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (melatonin receptor agonist class)

Apnimed · 1 drug in this class
Federico II University · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Period B — Competitive Intelligence Brief. https://druglandscape.com/ci/period-b. Accessed 2026-05-13.

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