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meloset (melatonin)
Melatonin binds to melatonin receptors (MT1 and MT2) in the brain to regulate circadian rhythm and promote sleep.
Melatonin binds to melatonin receptors (MT1 and MT2) in the brain to regulate circadian rhythm and promote sleep. Used for Insomnia and sleep disorders, Circadian rhythm sleep disorders.
At a glance
| Generic name | meloset (melatonin) |
|---|---|
| Sponsor | B.P. Koirala Institute of Health Sciences |
| Drug class | Melatonin receptor agonist |
| Target | MT1 and MT2 receptors |
| Modality | Small molecule |
| Therapeutic area | Neurology / Sleep Medicine |
| Phase | FDA-approved |
Mechanism of action
Melatonin is an endogenous hormone produced by the pineal gland that acts as a circadian rhythm regulator. It binds to MT1 and MT2 receptors in the suprachiasmatic nucleus and other tissues, signaling the body that it is nighttime and promoting the transition to sleep. Exogenous melatonin supplementation helps restore or regulate disrupted sleep-wake cycles.
Approved indications
- Insomnia and sleep disorders
- Circadian rhythm sleep disorders
Common side effects
- Headache
- Dizziness
- Drowsiness
- Nausea
Key clinical trials
- Premedication With Melatonin and Alprazolam Combination Versus Alprazolam or Melatonin Alone (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |