{"id":"meloset-melatonin","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Drowsiness"},{"rate":null,"effect":"Nausea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Melatonin is an endogenous hormone produced by the pineal gland that acts as a circadian rhythm regulator. It binds to MT1 and MT2 receptors in the suprachiasmatic nucleus and other tissues, signaling the body that it is nighttime and promoting the transition to sleep. Exogenous melatonin supplementation helps restore or regulate disrupted sleep-wake cycles.","oneSentence":"Melatonin binds to melatonin receptors (MT1 and MT2) in the brain to regulate circadian rhythm and promote sleep.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:41:29.584Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Insomnia and sleep disorders"},{"name":"Circadian rhythm sleep disorders"}]},"trialDetails":[{"nctId":"NCT01486615","phase":"PHASE4","title":"Premedication With Melatonin and Alprazolam Combination Versus Alprazolam or Melatonin Alone","status":"COMPLETED","sponsor":"B.P. Koirala Institute of Health Sciences","startDate":"2011-10","conditions":"Anxiety","enrollment":80}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":34719,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"meloset (melatonin)","genericName":"meloset (melatonin)","companyName":"B.P. Koirala Institute of Health Sciences","companyId":"b-p-koirala-institute-of-health-sciences","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Melatonin binds to melatonin receptors (MT1 and MT2) in the brain to regulate circadian rhythm and promote sleep. Used for Insomnia and sleep disorders, Circadian rhythm sleep disorders.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}