Who are Oxycodone and acetaminophen combination treatment's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): BENZHYDROCODONE, hydrocodone/APAP, Tramadol hydrochloride/ Acetaminophen, PCM/Oxy1, Bupivacaine-fentanyl elective group, Codeine/acetaminophen.

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Last reviewed 2026-06-10 · How we verify

Oxycodone and acetaminophen combination treatment — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Oxycodone and acetaminophen combination treatment (Oxycodone and acetaminophen combination treatment) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Opioid analgesic combination. Area: Pain Management.

marketed Opioid analgesic combination Mu opioid receptor (oxycodone); cyclooxygenase enzymes (acetaminophen) Pain Management Small molecule Live · refreshed every 30 min

Target snapshot

Oxycodone and acetaminophen combination treatment (Oxycodone and acetaminophen combination treatment) — Barrie Urology Associates. Oxycodone binds to opioid receptors to reduce pain perception, while acetaminophen inhibits prostaglandin synthesis to provide additional analgesic and antipyretic effects.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Oxycodone and acetaminophen combination treatment TARGET	Oxycodone and acetaminophen combination treatment	Barrie Urology Associates	marketed	Opioid analgesic combination	Mu opioid receptor (oxycodone); cyclooxygenase enzymes (acetaminophen)
BENZHYDROCODONE	BENZHYDROCODONE		marketed	Opioid analgesic combination; full mu-opioid agonist with non-opioid analgesic	Mu-opioid receptors (primary); delta and kappa opioid receptors (secondary); central nervous system pain pathways	2018-01-01
hydrocodone/APAP	hydrocodone/APAP	VA Office of Research and Development	marketed	Opioid analgesic combination	Mu opioid receptor (hydrocodone); COX inhibitor (acetaminophen)
Tramadol hydrochloride/ Acetaminophen	Tramadol hydrochloride/ Acetaminophen	Janssen Korea, Ltd., Korea	marketed	Opioid analgesic combination	Mu-opioid receptor; norepinephrine transporter; serotonin transporter
PCM/Oxy1	PCM/Oxy1	Maastricht University Medical Center	marketed	Opioid analgesic combination	Mu opioid receptor (oxycodone); COX enzymes (paracetamol)
Bupivacaine-fentanyl elective group	Bupivacaine-fentanyl elective group	Conrad Arnfinn Bjørshol	marketed	Local anesthetic with opioid analgesic combination	Voltage-gated sodium channels (bupivacaine); mu opioid receptor (fentanyl)
Codeine/acetaminophen	Codeine/acetaminophen	Montefiore Medical Center	marketed	Opioid analgesic combination	Mu-opioid receptor (codeine); COX enzymes (acetaminophen)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Opioid analgesic combination class)

VA Office of Research and Development · 3 drugs in this class
Rothman Institute Orthopaedics · 2 drugs in this class
Labopharm Inc. · 2 drugs in this class
University of Rochester · 2 drugs in this class
Montefiore Medical Center · 2 drugs in this class
Maastricht University Medical Center · 2 drugs in this class
Henry Ford Health System · 1 drug in this class
Daewon Pharmaceutical Co., Ltd. · 1 drug in this class
Albert Einstein College of Medicine · 1 drug in this class
Johnson & Johnson Taiwan Ltd · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Oxycodone and acetaminophen combination treatment — Competitive Intelligence Brief. https://druglandscape.com/ci/oxycodone-and-acetaminophen-combination-treatment. Accessed 2026-06-10.

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Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing