Who are Modified Bolus 5-FU/LV with Irinotecan's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Dose dense AC, TC, TC chemotherapy, B arm (FLAG-IDA), Course B2 +Vin, Docetaxel/capecitabine followed by XEC.

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Last reviewed 2026-05-17 · How we verify

Modified Bolus 5-FU/LV with Irinotecan — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Modified Bolus 5-FU/LV with Irinotecan (Modified Bolus 5-FU/LV with Irinotecan) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Chemotherapy combination regimen. Area: Oncology.

phase 3 Chemotherapy combination regimen Thymidylate synthase (5-FU), Topoisomerase I (irinotecan) Oncology Small molecule Live · refreshed every 30 min

Target snapshot

Modified Bolus 5-FU/LV with Irinotecan (Modified Bolus 5-FU/LV with Irinotecan) — Pfizer. This combination regimen inhibits DNA synthesis through fluorouracil and topoisomerase I inhibition via irinotecan, with leucovorin enhancing fluorouracil efficacy.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
Modified Bolus 5-FU/LV with Irinotecan TARGET	Modified Bolus 5-FU/LV with Irinotecan	Pfizer	phase 3	Chemotherapy combination regimen	Thymidylate synthase (5-FU), Topoisomerase I (irinotecan)
Dose dense AC	Dose dense AC	Ottawa Hospital Research Institute	marketed	Chemotherapy combination regimen
TC	TC	AGO Study Group	marketed	Chemotherapy combination regimen
TC chemotherapy	TC chemotherapy	Agendia	marketed	Chemotherapy combination regimen
B arm (FLAG-IDA)	B arm (FLAG-IDA)	Polish Adult Leukemia Group	phase 3	Chemotherapy combination regimen
Course B2 +Vin	Course B2 +Vin	Children's Cancer Group, China	phase 3	Chemotherapy combination regimen
Docetaxel/capecitabine followed by XEC	Docetaxel/capecitabine followed by XEC	China Breast Cancer Clinical Study Group	phase 3	Chemotherapy combination regimen

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Chemotherapy combination regimen class)

Tianjin Medical University Cancer Institute and Hospital · 2 drugs in this class
Agendia · 1 drug in this class
Asan Medical Center · 1 drug in this class
Children's Cancer Group, China · 1 drug in this class
China Breast Cancer Clinical Study Group · 1 drug in this class
Fujian Medical University · 1 drug in this class
MIPO Clinic · 1 drug in this class
Nanjing Yoko Biomedical Co., Ltd. · 1 drug in this class
Ottawa Hospital Research Institute · 1 drug in this class
Pfizer · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Modified Bolus 5-FU/LV with Irinotecan — Competitive Intelligence Brief. https://druglandscape.com/ci/modified-bolus-5-fu-lv-with-irinotecan. Accessed 2026-05-17.

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