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TC
TC is a chemotherapy regimen combining docetaxel and cyclophosphamide, which work synergistically to inhibit cell division and induce apoptosis in cancer cells.
TC is a chemotherapy regimen combining docetaxel and cyclophosphamide, which work synergistically to inhibit cell division and induce apoptosis in cancer cells. Used for Breast cancer (adjuvant and neoadjuvant treatment).
At a glance
| Generic name | TC |
|---|---|
| Also known as | Paclitaxel/Carboplatin, Docetaxel plus cyclophosphamide |
| Sponsor | AGO Study Group |
| Drug class | Chemotherapy combination regimen |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | FDA-approved |
Mechanism of action
Docetaxel is a taxane that stabilizes microtubules and prevents their disassembly, disrupting mitotic spindle formation. Cyclophosphamide is an alkylating agent that cross-links DNA, preventing replication. Together, they provide complementary cytotoxic mechanisms commonly used in breast cancer treatment.
Approved indications
- Breast cancer (adjuvant and neoadjuvant treatment)
Common side effects
- Neutropenia
- Alopecia
- Nausea and vomiting
- Fatigue
- Mucositis
- Peripheral neuropathy
- Febrile neutropenia
Key clinical trials
- Single-arm, Prospective Clinical Trial of Efficacy and Safety of Daphnetin Capsules Combined With TC Regimen for Targeted Maintenance Therapy After Initial Treatment of Stage III-IV Epithelial Ovarian Cancer (RO/R1) (NA)
- Testing the Safety of the Anti-cancer Drug, Sn-117m-DTPA, for Advanced Cancers That Have Spread to Bones (PHASE1)
- A Study to Evaluate Patient-Reported Satisfaction, Effectiveness, and Safety of Atezolizumab in Participants Treated in Routine Clinical Practice
- Repurposing Tilmanocept for Cardiac Sarcoidosis (PHASE2)
- Efficacy and Safety of a Botanical Total Coumarin (TC) Cream in Treating Patients With Psoriasis Vulgaris (PLANTCOAT-IIb Trial) (PHASE2)
- A Study of IMU-201 (PD1-Vaxx), a B-Cell Immunotherapy, in Adults With Non-Small Cell Lung Cancer (PHASE1)
- Telehealth Parent-Implemented Intervention for Young Children With Autism Spectrum Disorder (ASD) (NA)
- Imaging Phosphodiesterase 4B (PDE4B) in People With Psychiatric Disorders With Positron Emission Tomography (PET) and the Radiotracer [18F]PF974
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |