LPV/RTV pellets and AZT/3TC or ABC/3TC — Competitive Intelligence Brief

LPV/RTV pellets and AZT/3TC or ABC/3TC (LPV/RTV pellets and AZT/3TC or ABC/3TC) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Antiretroviral combination therapy (protease inhibitor + nucleoside reverse transcriptase inhibitors). Area: Infectious Disease / Virol

phase 3 Antiretroviral combination therapy (protease inhibitor + nucleoside reverse transcriptase inhibitors) HIV protease, HIV reverse transcriptase Infectious Disease / Virology Small molecule

Target snapshot

LPV/RTV pellets and AZT/3TC or ABC/3TC (LPV/RTV pellets and AZT/3TC or ABC/3TC) — Drugs for Neglected Diseases. This combination therapy uses protease inhibitors (lopinavir/ritonavir) to block HIV protease, combined with nucleoside reverse transcriptase inhibitors (AZT/3TC or ABC/3TC) to inhibit viral replication at multiple steps.

Comparator set (6 drugs)

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
LPV/RTV pellets and AZT/3TC or ABC/3TC TARGET	LPV/RTV pellets and AZT/3TC or ABC/3TC	Drugs for Neglected Diseases	phase 3	Antiretroviral combination therapy (protease inhibitor + nucleoside reverse transcriptase inhibitors)	HIV protease, HIV reverse transcriptase
Reyataz + Norvir + Truvada	Reyataz + Norvir + Truvada	ViiV Healthcare	marketed	Antiretroviral combination therapy (protease inhibitor + nucleoside reverse transcriptase inhibitors)	HIV protease, HIV reverse transcriptase
Atazanavir/ Stavidine / Lamivudine	Atazanavir/ Stavidine / Lamivudine	Bristol-Myers Squibb	marketed	Antiretroviral combination therapy (protease inhibitor + nucleoside reverse transcriptase inhibitors)	HIV protease, HIV reverse transcriptase
Atazanavir, ritonavir, lamivudine	Atazanavir, ritonavir, lamivudine	Catholic University of the Sacred Heart	marketed	Antiretroviral combination (protease inhibitor + NRTI)	HIV protease, HIV reverse transcriptase
Darunavir, Ritonavir and Rilpivirine	Darunavir, Ritonavir and Rilpivirine	St Stephens Aids Trust	marketed	Antiretroviral combination (protease inhibitor + NNRTI)	HIV protease, HIV reverse transcriptase
Darunavir, Ritonavir and Etravirine	Darunavir, Ritonavir and Etravirine	Imperial College London	marketed	Antiretroviral combination (protease inhibitor + NNRTI)	HIV protease, HIV reverse transcriptase
Atazanavir / Ritonavir + Tenofovir / Emtricitabine	Atazanavir / Ritonavir + Tenofovir / Emtricitabine	Juan A. Arnaiz	marketed	Antiretroviral combination (protease inhibitor + nucleoside/nucleotide reverse transcriptase inhibitors)	HIV protease, HIV reverse transcriptase

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Antiretroviral combination therapy (protease inhibitor + nucleoside reverse transcriptase inhibitors) class)

1. Bristol-Myers Squibb · 3 drugs in this class
2. Juan A. Arnaiz · 2 drugs in this class
3. National Institute of Allergy and Infectious Diseases (NIAID) · 1 drug in this class
4. The HIV Netherlands Australia Thailand Research Collaboration · 1 drug in this class
5. University of Cologne · 1 drug in this class
6. Amsterdam UMC, location VUmc · 1 drug in this class
7. ViiV Healthcare · 1 drug in this class
8. Drugs for Neglected Diseases · 1 drug in this class